2026-11-07_00000185|ligand|9T3W

Crystal structure of human soluble epoxide hydrolase C-terminal domain in complex with a benzoic acid inhibitor; X-ray diffraction 2.30Å
Protein #1 344 residues (92% resolved)

MHHHHHHSTENLYFQGSSTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM

MHHHHHHSTENLYFQGSSTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
Non polymer #2 A1JTF

InChI=1S/C29H32FN3O4/c30-28-13-20-15-29(17-28,16-21(14-28)24-4-2-1-3-23(20)24)32-27(37)31-22-9-11-33(12-10-22)25(34)18-5-7-19(8-6-18)26(35)36/h1-8,20-22H,9-17H2,(H,35,36)(H2,31,32,37)/t20-,21+,28+,29-

c1ccc2c(c1)[C@@H]3CC4(C[C@H]2CC(C3)(C4)F)NC(=O)NC5CCN(CC5)C(=O)c6ccc(cc6)C(=O)O
Download coordinates
Download coordinates
Reference