2026-11-07_00000184|ligand|9T3V

Crystal structure of human soluble epoxide hydrolase C-terminal domain in complex with an N-benzylpiperidine-based inhibitor; X-ray diffraction 1.90Å
Protein #1 344 residues (92% resolved)

MHHHHHHSTENLYFQGSSTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM

MHHHHHHSTENLYFQGSSTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
Non polymer #2 A1JTG

InChI=1S/C28H33ClFN3O/c29-22-7-5-19(6-8-22)17-33-11-9-23(10-12-33)31-26(34)32-28-15-20-13-27(30,18-28)14-21(16-28)25-4-2-1-3-24(20)25/h1-8,20-21,23H,9-18H2,(H2,31,32,34)/t20-,21+,27+,28-

c1ccc2c(c1)[C@@H]3CC4(C[C@H]2CC(C3)(C4)F)NC(=O)NC5CCN(CC5)Cc6ccc(cc6)Cl
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Reference