2026-11-07_00000183|ligand|9T3U

Crystal structure of human soluble epoxide hydrolase C-terminal domain in complex with a TPPU-6-chlorotacrine hybrid; X-ray diffraction 2.00Å
Protein #1 344 residues (92% resolved)

MHHHHHHSTENLYFQGSSTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM

MHHHHHHSTENLYFQGSSTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
Non polymer #2 A1JTE

InChI=1S/C31H38ClN5O4S/c1-42(40,41)24-12-10-22(11-13-24)34-31(39)35-23-15-18-37(19-16-23)29(38)8-4-5-17-33-30-25-6-2-3-7-27(25)36-28-20-21(32)9-14-26(28)30/h9-14,20,23H,2-8,15-19H2,1H3,(H,33,36)(H2,34,35,39)

CS(=O)(=O)c1ccc(cc1)NC(=O)NC2CCN(CC2)C(=O)CCCCNc3c4ccc(cc4nc5c3CCCC5)Cl
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Reference