2026-11-07_00000086|ligand|34CM

Crystal structure of human Cathepsin L in complex with 8-hydroxy-2,6-diazaspiro[3.5]nonan-5-one; X-ray diffraction 1.70Å

Protein #1 220 residues (100% resolved)

Raw Sequence ...

APRSVDWREKGYVTPVKNQGQCGS(CSO)WAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDAGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV

Canonical Sequence ...

APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDAGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV

Non polymer #2 1PE

InChI=1S/C10H22O6/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h11-12H,1-10H2

SMILES: C(COCCOCCOCCOCCO)O

C(COCCOCCOCCOCCO)O

Non polymer #3 A1KPM

InChI=1S/C7H12N2O2/c10-5-1-7(3-8-4-7)6(11)9-2-5/h5,8,10H,1-4H2,(H,9,11)/t5-/m1/s1

SMILES: C1[C@H](CNC(=O)C12CNC2)O

C1[C@H](CNC(=O)C12CNC2)O

Non polymer #4 A1KTO

InChI=1S/C7H12N2O2/c10-5-1-7(3-8-4-7)6(11)9-2-5/h5,8,10H,1-4H2,(H,9,11)/t5-/m0/s1

SMILES: C1[C@@H](CNC(=O)C12CNC2)O

C1[C@@H](CNC(=O)C12CNC2)O

Non polymer #5 DMS

InChI=1S/C2H6OS/c1-4(2)3/h1-2H3

SMILES: CS(=O)C

CS(=O)C

Non polymer #6 EDO

InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

SMILES: C(CO)O

C(CO)O

Non polymer #7 PEG

InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

SMILES: C(COCCO)O

C(COCCO)O

Non polymer #8 PG4

InChI=1S/C8H18O5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h9-10H,1-8H2

SMILES: C(COCCOCCOCCO)O

C(COCCOCCOCCO)O

Non polymer #9 PGE

InChI=1S/C6H14O4/c7-1-3-9-5-6-10-4-2-8/h7-8H,1-6H2

SMILES: C(COCCOCCO)O

C(COCCOCCO)O

Biounit #1 homo-tetramer

Reference