2026-11-07_00000078|ligand|32TH

Crystal structure of YTHDF2 in complex with compound 20 (ZA801); X-ray diffraction 1.68Å
Protein #1 167 residues (87% resolved)

MGSSYHHHHHHSSGENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTS

MGSSYHHHHHHSSGENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTS
Non polymer #2 A1KFC

InChI=1S/C17H15N3O3/c1-23-17(22)11-6-4-10(5-7-11)15-14-13(21)8-12(9-2-3-9)18-16(14)20-19-15/h4-9H,2-3H2,1H3,(H2,18,19,20,21)

COC(=O)c1ccc(cc1)c2c3c(n[nH]2)NC(=CC3=O)C4CC4
Non polymer #3 PEG

InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

C(COCCO)O
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Reference