2026-11-07_00000077|ligand|32SJ

Crystal structure of YTHDF2 in complex with compound 22 (FE-709); X-ray diffraction 2.20Å
Protein #1 167 residues (90% resolved)

MGSSYHHHHHHSSGENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTS

MGSSYHHHHHHSSGENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTS
Non polymer #2 A1KE0

InChI=1S/C19H17N5O/c25-16-9-15(13-4-5-13)21-19-17(16)18(22-23-19)14-3-1-2-12(8-14)10-24-7-6-20-11-24/h1-3,6-9,11,13H,4-5,10H2,(H2,21,22,23,25)

c1cc(cc(c1)c2c3c(n[nH]2)NC(=CC3=O)C4CC4)Cn5ccnc5
Non polymer #3 CL

InChI=1S/ClH/h1H/p-1

[Cl-]
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Reference