2026-11-07_00000076|ligand|32SH

Crystal structure of YTHDF2 in complex with compound 4 (FE-462); X-ray diffraction 1.61Å
Protein #1 167 residues (90% resolved)

MGSSYHHHHHHSSGENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTS

MGSSYHHHHHHSSGENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTS
Non polymer #2 A1KFA

InChI=1S/C8H9N3O/c1-2-5-3-7(12)6-4-9-11-8(6)10-5/h3-4H,2H2,1H3,(H2,9,10,11,12)

CCC1=CC(=O)c2c[nH]nc2N1
Non polymer #3 CL

InChI=1S/ClH/h1H/p-1

[Cl-]
Download coordinates
Download coordinates
Reference