2026-11-07_00000073|ligand|32QY

Crystal structure of YTHDF2 in complex with compound 24 (FE-593); X-ray diffraction 1.84Å
Protein #1 167 residues (90% resolved)

MGSSYHHHHHHSSGENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTS

MGSSYHHHHHHSSGENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTS
Non polymer #2 A1KEO

InChI=1S/C12H10N4O2/c1-6-4-8(17)10-11(15-16-12(10)14-6)7-2-3-9(18)13-5-7/h2-5H,1H3,(H,13,18)(H2,14,15,16,17)

CC1=CC(=O)c2c([nH]nc2N1)C3=CNC(=O)C=C3
Non polymer #3 CL

InChI=1S/ClH/h1H/p-1

[Cl-]
Download coordinates
Download coordinates
Reference