2026-11-07_00000068|hard|31LY

Yersinia entomophaga holotoxin in its lollipop pore state; Electron microscopy 2.94Å
Protein #1 1364 residues (34% resolved)

MSNSIEAKLQEDLRDALVDYYLGQIVPNSKDFTNLRSTIKNVDDLYDHLLLDTQVSAKVITSRLSLVTQSVQQYINRIALNLEPGLSINQQEATDWEEFANRYGYWAANQQLRMFPEIYVDPTLRLTKTEFFFQLESALNQGKLTDDVAQKAVLGYLNNFEEVSNLEIIAGYQDGIDIENDKTYFVARTRMQPYRYFWRSLDASQRNANSQELYPTAWSEWKAISVPLENVANGIVRPIMMDNRLYISWFEVAEEKETDSDGNIIVSGRYRTKIRLAHLGFDGVWSSGTTLREEVLADQMEEMIAVVDRMEDEPRLALVAFKEMSESWDVVFSYICDSMLIESSNLPTTTHPPKPGDGDKGLSDLDDYGANLVWFYLHETANGGKAEYKQLILYPVIINRDWPIELDKTHQGDFGTVDDFTLNSNYTGDELSLYLQSSSTYKYDFSKSKNIIYGIWKEDANNNRCWLNYKLLTPEDYEPQINATLVMCDKGDVNIITGFSLPNGGVDAGGKIKVTLRVGKKLRDKFQIKQFSQTQYLQFPEASSADVWYIGKQIRLNTLFAKELIGKASRSLDLVLSWETQNSRLEEAILGGAAELIDLDGANGIYFWELFFHMPFMVSWRFNVEQRYEDANRWVKYLFNPFECEDEPALLLGKPPYWNSRPLVDEPFKGYSLTQPSDPDAIAASDPIHYRKAVFNFLTKNIIDQGDMEYRKLQPSARTLARLSYSTASSLLGRRPDVQLTSFWQPLTLEDASYKTDSEIRAIEMQSQPLTFEPVVHDQTMSAVDNDIFMYPMNNELRGLWDRIENRIYNLRHNLTLDGKEINMDLYDSSISPRGLMKQRYQRVVTARNASKMNFKVPNYRFEPMLNRSKSGVETLIQFGSTLLSLLERKDSLSFDAYQMIQSGDLYRFSIDLQQQDIDINKASLEALQVSKQSAQDRYDHFKELYDENISSTEQKVIELQSQAANSLLMAQGMRTAAAALDVIPNIYGLAVGGSHWGAPLNAAAEIIMIKYQADSSKSESLSVSESYRRRRQEWELQYKQAEWEVNSVEQQINLQNMQIKAANKRLEQVEAQQQQAMALLDYFSERFTNESLYTWLISQLSSLYLQAYDAVLSLCLSAEASLLYELNLGEQSFVGGGGWNDLYQGLMAGETLKLALMRMERVYVEQNSRRQEITKTISLKALLGESWPAELNKLKQKTPINFNLEEQIFVEDYQELYQRRIKSVSVSLPMLVGPYEDVCAQLTQTSSSYSTRADLKTVENMLTKRTFADTPHLVRSIQPNQQISLSTGVNDSGLFMLNFDDERFLPFEGSGVDSSWRLQFTNLKQNLDSLNDVILHVKYTAAIGSSTFSQGVRKILANINNDE

MSNSIEAKLQEDLRDALVDYYLGQIVPNSKDFTNLRSTIKNVDDLYDHLLLDTQVSAKVITSRLSLVTQSVQQYINRIALNLEPGLSINQQEATDWEEFANRYGYWAANQQLRMFPEIYVDPTLRLTKTEFFFQLESALNQGKLTDDVAQKAVLGYLNNFEEVSNLEIIAGYQDGIDIENDKTYFVARTRMQPYRYFWRSLDASQRNANSQELYPTAWSEWKAISVPLENVANGIVRPIMMDNRLYISWFEVAEEKETDSDGNIIVSGRYRTKIRLAHLGFDGVWSSGTTLREEVLADQMEEMIAVVDRMEDEPRLALVAFKEMSESWDVVFSYICDSMLIESSNLPTTTHPPKPGDGDKGLSDLDDYGANLVWFYLHETANGGKAEYKQLILYPVIINRDWPIELDKTHQGDFGTVDDFTLNSNYTGDELSLYLQSSSTYKYDFSKSKNIIYGIWKEDANNNRCWLNYKLLTPEDYEPQINATLVMCDKGDVNIITGFSLPNGGVDAGGKIKVTLRVGKKLRDKFQIKQFSQTQYLQFPEASSADVWYIGKQIRLNTLFAKELIGKASRSLDLVLSWETQNSRLEEAILGGAAELIDLDGANGIYFWELFFHMPFMVSWRFNVEQRYEDANRWVKYLFNPFECEDEPALLLGKPPYWNSRPLVDEPFKGYSLTQPSDPDAIAASDPIHYRKAVFNFLTKNIIDQGDMEYRKLQPSARTLARLSYSTASSLLGRRPDVQLTSFWQPLTLEDASYKTDSEIRAIEMQSQPLTFEPVVHDQTMSAVDNDIFMYPMNNELRGLWDRIENRIYNLRHNLTLDGKEINMDLYDSSISPRGLMKQRYQRVVTARNASKMNFKVPNYRFEPMLNRSKSGVETLIQFGSTLLSLLERKDSLSFDAYQMIQSGDLYRFSIDLQQQDIDINKASLEALQVSKQSAQDRYDHFKELYDENISSTEQKVIELQSQAANSLLMAQGMRTAAAALDVIPNIYGLAVGGSHWGAPLNAAAEIIMIKYQADSSKSESLSVSESYRRRRQEWELQYKQAEWEVNSVEQQINLQNMQIKAANKRLEQVEAQQQQAMALLDYFSERFTNESLYTWLISQLSSLYLQAYDAVLSLCLSAEASLLYELNLGEQSFVGGGGWNDLYQGLMAGETLKLALMRMERVYVEQNSRRQEITKTISLKALLGESWPAELNKLKQKTPINFNLEEQIFVEDYQELYQRRIKSVSVSLPMLVGPYEDVCAQLTQTSSSYSTRADLKTVENMLTKRTFADTPHLVRSIQPNQQISLSTGVNDSGLFMLNFDDERFLPFEGSGVDSSWRLQFTNLKQNLDSLNDVILHVKYTAAIGSSTFSQGVRKILANINNDE
Protein #2 1487 residues (99% resolved)

MQNSQEMAITTLSLPKGGGAINGMGESVGQAGPDGMVTFSIPLPFSAGRGVAPALSLSYSSGAGNGPFGMGWQCSAMSISRRTQKGVPQYNEDDEFLSPSGEVMAIALNDSGFEDVRTANRLQGIPLPFSYKVTRYQPRLIQDFIKIEYWQPVKQTDGTPFWIIYSPDGQTHILGKNSHSRVANAENPSQIASWLLEETVTPTGEHIYYQYSGENQVNCTDAEIALHPQDSAQRYLARIDYGNISPQASLFVLDEELPNLTQWLFHLVFDYGERDISINKIPTFEGGTTGWLARPDMFSRYDFGIEIRNRRLCHQVLGFHRLEALNDRDVTDEIPVLVNRLTLDYDLNNSVSTLVAVRQVAYETDGSPITQPPLEFDYQRFDTGSIPGWQEMPQLEAFNGYQPYQMIDLYGEGTPGILYQETPGAWWYKSPQRQIGGDSNAVTYGAMKALPKIPRLQEGATLMDINGDGRLDWVITSAGVRGFHSIHSTGEWTHFTPLNTLPTEYFHPKAQLADLVGAGLSDLVLIGPKSVRLYANQQGNWAPAQDVTQAENVSLPVIGIDSRQLVAFADMLGSGQQHLVEITADSVKCWPNMGHGRFGQPLTLEGFSQPQTSFNPDRVFLADIDGSGTNDIIYAHSECLEIYLNESGNRFSKPISLLLPDGVNFDNTCQLQAADIQGLGIASLVMTVPHMSPTHWRCDLALNKPWLLNVMNNNRGAETCLFYRSSAQFWLDEKQLVEAAGQQPECHLPFPMHLHWRSEIFDEITGNRLTQEQEYAHGSWDGQEREFRGFGRLIQRDTDGFAQGTVDIPTHPSRTVSWFATGIPEIDTTLSAEFWRGDDQAFSPFSPRFTRWENDSEAGSDVAFIPSEHDAFWLNRAMKGQLLRSELYGDDGTPEAEIPYSVTEMRHQVRALPTTDATVPSAWCSTIETRSYQYQRVAADPQCSQQVVIKADRYGSPLLSVAINYPRRKKPEKSPYPDDLPETLFDSSYDTQQQQLHLTKQQQNYFHLTNDDNWLLGLPKEQRNDGYQYDQERAPANGFTLETLIASNSLIGSNQPFTYLGQSRVAYQGGVDEQPSLQALVAYGETAILDEKTLQAFVGVLDSKTRDELLFSAGYQLAPRLFRVESEPDVWVARQGYSEFGDYSQFWRPLSQRSTLLTGKTTLKWDKHYCVVIETQDAAQLVTQARYDYRFLTPYSLTDANDNQHYVVLNPFGEVIASRFWGTEAGKDAGYSTPQAKPFVVPATIEAALALSPGIPVAHCAIFEPESWMQKLTQHDVSERMADNGTLWNALLQARFVTEDGYVCALGRRRWMARHGLSVLMLTLLAEIPRTPPHSLTITTDRYDSDDQQQLRQRILFSDGFGRLLQSAQRVEAGESWQRSEDSSLVVNVSGTPALVVTDNRWAVSGRTEYDGKGQGIRVYQPYFLDDWRYLSDDSARTDLFADTHIYDPLGREYQVITAKGYRRERQYTPWFVVNQDENDTAADLAI

MQNSQEMAITTLSLPKGGGAINGMGESVGQAGPDGMVTFSIPLPFSAGRGVAPALSLSYSSGAGNGPFGMGWQCSAMSISRRTQKGVPQYNEDDEFLSPSGEVMAIALNDSGFEDVRTANRLQGIPLPFSYKVTRYQPRLIQDFIKIEYWQPVKQTDGTPFWIIYSPDGQTHILGKNSHSRVANAENPSQIASWLLEETVTPTGEHIYYQYSGENQVNCTDAEIALHPQDSAQRYLARIDYGNISPQASLFVLDEELPNLTQWLFHLVFDYGERDISINKIPTFEGGTTGWLARPDMFSRYDFGIEIRNRRLCHQVLGFHRLEALNDRDVTDEIPVLVNRLTLDYDLNNSVSTLVAVRQVAYETDGSPITQPPLEFDYQRFDTGSIPGWQEMPQLEAFNGYQPYQMIDLYGEGTPGILYQETPGAWWYKSPQRQIGGDSNAVTYGAMKALPKIPRLQEGATLMDINGDGRLDWVITSAGVRGFHSIHSTGEWTHFTPLNTLPTEYFHPKAQLADLVGAGLSDLVLIGPKSVRLYANQQGNWAPAQDVTQAENVSLPVIGIDSRQLVAFADMLGSGQQHLVEITADSVKCWPNMGHGRFGQPLTLEGFSQPQTSFNPDRVFLADIDGSGTNDIIYAHSECLEIYLNESGNRFSKPISLLLPDGVNFDNTCQLQAADIQGLGIASLVMTVPHMSPTHWRCDLALNKPWLLNVMNNNRGAETCLFYRSSAQFWLDEKQLVEAAGQQPECHLPFPMHLHWRSEIFDEITGNRLTQEQEYAHGSWDGQEREFRGFGRLIQRDTDGFAQGTVDIPTHPSRTVSWFATGIPEIDTTLSAEFWRGDDQAFSPFSPRFTRWENDSEAGSDVAFIPSEHDAFWLNRAMKGQLLRSELYGDDGTPEAEIPYSVTEMRHQVRALPTTDATVPSAWCSTIETRSYQYQRVAADPQCSQQVVIKADRYGSPLLSVAINYPRRKKPEKSPYPDDLPETLFDSSYDTQQQQLHLTKQQQNYFHLTNDDNWLLGLPKEQRNDGYQYDQERAPANGFTLETLIASNSLIGSNQPFTYLGQSRVAYQGGVDEQPSLQALVAYGETAILDEKTLQAFVGVLDSKTRDELLFSAGYQLAPRLFRVESEPDVWVARQGYSEFGDYSQFWRPLSQRSTLLTGKTTLKWDKHYCVVIETQDAAQLVTQARYDYRFLTPYSLTDANDNQHYVVLNPFGEVIASRFWGTEAGKDAGYSTPQAKPFVVPATIEAALALSPGIPVAHCAIFEPESWMQKLTQHDVSERMADNGTLWNALLQARFVTEDGYVCALGRRRWMARHGLSVLMLTLLAEIPRTPPHSLTITTDRYDSDDQQQLRQRILFSDGFGRLLQSAQRVEAGESWQRSEDSSLVVNVSGTPALVVTDNRWAVSGRTEYDGKGQGIRVYQPYFLDDWRYLSDDSARTDLFADTHIYDPLGREYQVITAKGYRRERQYTPWFVVNQDENDTAADLAI
Protein #3 970 residues (68% resolved)

MDIQLFSKTPSVTVFDNRGLSVRDIAYRRHPDTPKVTEECITYHQFDFRGFLAQSLDPRLNHKEVTNFSYLTDLNGNIIYTQSVDAGNTLVLNDTEGRSVIAMTNISRGENGSDDLSLAVTRTFQYENAPLPGRPLSVTEQVNGENARITEHFVYAGNTPQEKNLNLAGQCVSYYDAAGLIQTDSVSLTGKPLSVSRKLLKNLDDTNILADWQGNDTSAWNSLLATEIYTTVTRTDAAGAVLTTIDAVGNQQRVAFDIAGQLSASWLTLKGGQEQVIIKVLTYSAAGQKLREEGGNGVVTTYTYEAETQRLIGIKTERPNGHAAGAKVLQDLRYEYDPVGNVLSITNDAEETRFWRNQKVVPENAYRYDSLYQLVSASGREVAGAGQQGSDLPSPLVPLPSDSSVYTNYTRTYTYDSAGNLMRIRHSAPATNNNYTLNITVSERSNRGVMSSLTENPADVDALFTASGSQKCLQQGQSLIWTPRGELRTVLLVARGETADDSESYRYDGSSQRILKISSQQTNHSARVQRALYLPGLEWRTMTGGVAEAENLQVICIGEAGRAQVRVLHWESGKPDGIINDQIRWSYDNLTCSSGLEVDGDGLVISMEEYYPYGGTAVWAARSHIETAYKTVRYSGKERDATGLYYYGFRYYQPWAGRWLSADPAGTVDGLNLYRMVRNNPLRLTDPDGMAPLDWLDLDTTNASRDIVKAIYQLNQIDGPHRGVRDTYQRMTESTGMILQETLNNEAVLKGIKQKDKEKKSRGMKFTNSKLKTYAAHAGVLNTLQPDPVYKDGFLNLPGSLGNKNTFPGVELIEDKVKPSLSQYHPDKLGKSQRWKPESSLGYYRVADTEAFITGIRSQYKSSGTDLHAVVEGRIRDHLLANNNVLPKMAGIAGLHAEVQALNYIISNPDIEGGNAERLNGSYIFTQRLVGDVNQDFPACYNCSGIISGLENVMTGRVNNDVRLKRRKSF

MDIQLFSKTPSVTVFDNRGLSVRDIAYRRHPDTPKVTEECITYHQFDFRGFLAQSLDPRLNHKEVTNFSYLTDLNGNIIYTQSVDAGNTLVLNDTEGRSVIAMTNISRGENGSDDLSLAVTRTFQYENAPLPGRPLSVTEQVNGENARITEHFVYAGNTPQEKNLNLAGQCVSYYDAAGLIQTDSVSLTGKPLSVSRKLLKNLDDTNILADWQGNDTSAWNSLLATEIYTTVTRTDAAGAVLTTIDAVGNQQRVAFDIAGQLSASWLTLKGGQEQVIIKVLTYSAAGQKLREEGGNGVVTTYTYEAETQRLIGIKTERPNGHAAGAKVLQDLRYEYDPVGNVLSITNDAEETRFWRNQKVVPENAYRYDSLYQLVSASGREVAGAGQQGSDLPSPLVPLPSDSSVYTNYTRTYTYDSAGNLMRIRHSAPATNNNYTLNITVSERSNRGVMSSLTENPADVDALFTASGSQKCLQQGQSLIWTPRGELRTVLLVARGETADDSESYRYDGSSQRILKISSQQTNHSARVQRALYLPGLEWRTMTGGVAEAENLQVICIGEAGRAQVRVLHWESGKPDGIINDQIRWSYDNLTCSSGLEVDGDGLVISMEEYYPYGGTAVWAARSHIETAYKTVRYSGKERDATGLYYYGFRYYQPWAGRWLSADPAGTVDGLNLYRMVRNNPLRLTDPDGMAPLDWLDLDTTNASRDIVKAIYQLNQIDGPHRGVRDTYQRMTESTGMILQETLNNEAVLKGIKQKDKEKKSRGMKFTNSKLKTYAAHAGVLNTLQPDPVYKDGFLNLPGSLGNKNTFPGVELIEDKVKPSLSQYHPDKLGKSQRWKPESSLGYYRVADTEAFITGIRSQYKSSGTDLHAVVEGRIRDHLLANNNVLPKMAGIAGLHAEVQALNYIISNPDIEGGNAERLNGSYIFTQRLVGDVNQDFPACYNCSGIISGLENVMTGRVNNDVRLKRRKSF
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Reference