2026-10-31_00000739
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ligand
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9SYX
Crystal structure of PD-2018 bound METTL3-METTL14 complex;
X-ray diffraction 2.14Å
Protein #1
225 residues (88% resolved)
Raw Sequence ...
MQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQKYPDGIISKPKNL
Canonical Sequence ...
MQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQKYPDGIISKPKNL
Protein #2
290 residues (91% resolved)
Raw Sequence ...
MQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKS
Canonical Sequence ...
MQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKS
Non polymer #3
A1JR4
InChI=1S/C28H33N5O2/c34-27-16-25(30-26-6-1-2-13-33(26)27)28(35)29-23-11-14-32(15-12-23)24-9-7-20(8-10-24)17-31-18-21-4-3-5-22(21)19-31/h1-2,6-10,13,16,21-23H,3-5,11-12,14-15,17-19H2,(H,29,35)/t21-,22+
InChI=1S/C28H33N5O2/c34-27-16-25(30-26-6-1-2-13-33(26)27)28(35)29-23-11-14-32(15-12-23)24-9-7-20(8-10-24)17-31-18-21-4-3-5-22(21)19-31/h1-2,6-10,13,16,21-23H,3-5,11-12,14-15,17-19H2,(H,29,35)/t21-,22+
SMILES: c1cc(ccc1CN2C[C@H]3CCC[C@H]3C2)N4CCC(CC4)NC(=O)C5=CC(=O)N6C=CC=CC6=N5
c1cc(ccc1CN2C[C@H]3CCC[C@H]3C2)N4CCC(CC4)NC(=O)C5=CC(=O)N6C=CC=CC6=N5
Biounit #1
hetero-1-1-mer
Download coordinates
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Model
Reference
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