2026-10-31_00000641|ligand|37OC

PLK4-T170D (inactive) in complex with Cpd15; X-ray diffraction 1.69Å
Protein #1 278 residues (81% resolved)

SLATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDEG

SLATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDEG
Non polymer #2 A1DQE

InChI=1S/C22H25F4N7O2/c1-19(2,23)12-33-16-7-14(27-8-13(16)9-29-33)17-15(10-28-31-17)30-18(34)32-6-5-21(35,22(24,25)26)11-20(32)3-4-20/h7-10,35H,3-6,11-12H2,1-2H3,(H,28,31)(H,30,34)/t21-/m1/s1

CC(C)(Cn1c2cc(ncc2cn1)c3c(c[nH]n3)NC(=O)N4CC[C@@](CC45CC5)(C(F)(F)F)O)F
Non polymer #3 PO4

InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3

[O-]P(=O)([O-])[O-]
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Reference