2026-10-31_00000516|hard|27DN

Cryo-EM Structure of Hybrid NRPS-PKS Enzyme CorA from the myxobacterium Corallococcus exiguus; Electron microscopy 3.10Å
Protein #1 2867 residues (30% resolved)

MNSISSHPRLDIATLFEAHARNTPEAVALRFDGGVLTYDMLNRRANRLARRLQELGVGPDQPVGILADRTPETVVGLLGILKAGGAYLPLDPGHPQERLAAMVEDSGMRVLVGRREAVQGLRFQGHVVEPPAPDEQEAVNVKGGAGPDSLAYVLYTSGSTGRPKGVCIPHRGVARLVLDAGFMGFRREDRVLQAASYAFDASTLEVWGALLNGATLCLVSRETLLSPPLLAEKLRRDAISAAVLSTSLFHQLAAAIPDAFGGLRVLMVGGDVLDPKWVARVMAHGKPQRLLNSYGPTECTTSATAYEFLTPPEPGVSIPIGRPLAKLQLHVLDDAGRAQPVGEVGELYLGGEGLARGYLNRPVLTSERFLPDPFSGVLGARMYRTGDRARWLQDGNLEFLGRVDHQVKIRGARVELAEIESVLRTHPRVADAVVRVHEVSPGDKRLVAYVSPRGVEDAELRAYLGSKLPDFMLPHAVMALEHMPLNSSGKVDHSRLPAPRFGSGEGETPRTLLEQEIARVWSEVLGTQQAGTQDRFMESGGDSLLAIRFIERLEQAVSVRLPVRTLFDSPNIAELARWVEAARGTGRSLDVPPIVPVDRTRPLPLSDSQRQLWLLEQLAPRSAVYNEPFTLYLPGDLQPDALERAFRSLIARHEVLRTTFGSTPDGPFQRVHPDMPFHLRRVDLHAVPGSLRRAKALQVATQEAREPFDLEHGPLLRATWMRLSKAESRLALVMHHLIVDGFTMAAFLQELHQFYLAEAPSLPPLPLQYGDAAVWQQGARYQEAIAPHLGWWKQTLAGAPHLELPTQHPRPQVPSFRGARHVVRIPGDLLESVKALGRGEGASLFMTMLSVFGALLHRYSGAEDLVVGGAFSGRSREESQAISGHFVNLLPLRLRFSEGLTVRGLLEQVRRVCLEALEHQDAPLVRIVEAVNPARIPGANPLFQVSCTLEPRIAVPASDWRVEPHDVDTGTSKLDLSIELDERPDGMSVRWEYALDVFEPWMVHQLGQHFVTLLREASHDPEQLLSALPLLSEAEQSQVLAWAHGPAREVAHADCLHHPFEAQVERTPDAPALVFQGRPLSYRALDTEANRLAHHLISQGVRPGDFVGICVQRSFELIITLLAALKAGAAYVPLDPAYPRARLEFMARDAALRLILAQEATLALMDGMGVPVVALEQVRGGPEDAPRIHVTGDALAYVIYTSGSTGQPKGVCIGHRSAVHLTETVASDFGFAPGQRVAQCARYGFDFSVAEIFPTLSSGATLYLMGQEDVAAGAELADFLETHRIHTAMFTPSALASMPWRALPDLKTLAIGGEELPARLVDTWAPGRRFIQVYGPTEATVFTTTAECVAGDGPYPIGTPLPGYEVYLLDETLTPVPVGVRGALYIGGKGLAHGYLHRPELDAERFIPHPFSAEPGARLYKSGDIASHRPDGGIDFHGRSDRQLKLRGFRIELGEIEAALRQHPDVRDAVVEPRLIAGERHLVGYVIPRDAAVTPAFKESLGKTLPPHMIPREWVLLEAFPMGPTGKLDRNVLPLPSVKAPAAPESSVSTEREKALERIWCRILGVERVGRHEGFFDAGGSSLLLTRVQSALASELDIRVSMATLFQFPTLESLARHLDADSTVQPVTPEPTRSPVRSSDSIAIIGTAGRFPGAPSVEALWTLLVEGREGLSRFSRETLLAAGEDPQLLEDPSYVRASGLLEDVESFDAAFFGYSPLDARLMDPQLRMFLECAWEALEAAGYDPKRLPGKAGLFAGSGVPRYWLDQVMPRFRSLSVGSEAYRSILGNPWQFLATATAYQLGLRGPALTVQTACSTSLVAVHLACQSLRAGESDVALAGGISLFASGPSGYLHEAGGITSPDGHCRPFDAKGQGTVPSSGVGIVVLKRLEDALRDGDSIHAVIRGSAINNDGDAKVGFTAPSVEGQRDVITRAHADAGVAARDITYVEAHGTATPLGDPLEVQALRLAFGAREASEPAVVLGALKSNVGHLDSAAGVAGLIKTTLALEHRFLPGTVHFEQPHPEAGLERSPFVVSSEGRPWSLPEGFPRLAGVSAFGIGGTNAHVVLEEARPEPAVDVGPTVEVLVLSARSGEALSAASRRLADHLERHPEQSLADVAYTLQEGRTAFGYRRAIACETPGEAIAALRRDGPAQPAASPLPEVCFLFPGTGTQEAGMGAAWYRRAPAYREAFDACAALFGPELERDLRAALLTDERGAQAEEALRAPSLGMAAIFTTEYSLSRLLGAWGLHPTSLLGHSLGEYAAACLSGVLSLEQAVALVALRGRLCDALPPSGMLAVPLSEGVLTQELPPGLSLAAVNGPGQCVVSGALEALEDFAARLRERGVRTKRLPNASGFHSALVEPAMQPLTDLARSMRPKSPAIPLLSNVTGTWLTADDAHDRTYWARHLRHTVRFSQGLELLLEDRERIFVEVGPGQTLSTLTLLNPRAGRERLVLHTGRRHPPEGEEQALLQAVGQLWSAGLPVDWGAVRGSGPRRRVVLPTYPFERKRYSLAEKTPRPPRPEVTAAPRPLSREEVRASMEALWKELLGVDTLTPDSHFFQLGGTSLLVVQLNRELKTRLSVNLSLHAVLEHPTLGAWVRAVQDELERTGRPLTQAAPLRMALQEGRRGRTPLFLVQPIGGTVYTYLPLAKQLGADIPVHAFRASGLEPGEVLYRDVPAMARAYVDELLAFQPQGPFWLGGHSSGGVIAYEMAAELLKQGHSVAGVIQIDTVTVDDSRRLNVRSVGDVLQLVDAFQEISPRAAEGLRTAMEHDTRLRDVVLATNEAIAAYAPGRHAVPLVYLRASERDPVLDSHAAAWWKALTTASFQSHDVRGNHFTVMEEPHVAEVARLIRDTLTAGGERDDLDAG

MNSISSHPRLDIATLFEAHARNTPEAVALRFDGGVLTYDMLNRRANRLARRLQELGVGPDQPVGILADRTPETVVGLLGILKAGGAYLPLDPGHPQERLAAMVEDSGMRVLVGRREAVQGLRFQGHVVEPPAPDEQEAVNVKGGAGPDSLAYVLYTSGSTGRPKGVCIPHRGVARLVLDAGFMGFRREDRVLQAASYAFDASTLEVWGALLNGATLCLVSRETLLSPPLLAEKLRRDAISAAVLSTSLFHQLAAAIPDAFGGLRVLMVGGDVLDPKWVARVMAHGKPQRLLNSYGPTECTTSATAYEFLTPPEPGVSIPIGRPLAKLQLHVLDDAGRAQPVGEVGELYLGGEGLARGYLNRPVLTSERFLPDPFSGVLGARMYRTGDRARWLQDGNLEFLGRVDHQVKIRGARVELAEIESVLRTHPRVADAVVRVHEVSPGDKRLVAYVSPRGVEDAELRAYLGSKLPDFMLPHAVMALEHMPLNSSGKVDHSRLPAPRFGSGEGETPRTLLEQEIARVWSEVLGTQQAGTQDRFMESGGDSLLAIRFIERLEQAVSVRLPVRTLFDSPNIAELARWVEAARGTGRSLDVPPIVPVDRTRPLPLSDSQRQLWLLEQLAPRSAVYNEPFTLYLPGDLQPDALERAFRSLIARHEVLRTTFGSTPDGPFQRVHPDMPFHLRRVDLHAVPGSLRRAKALQVATQEAREPFDLEHGPLLRATWMRLSKAESRLALVMHHLIVDGFTMAAFLQELHQFYLAEAPSLPPLPLQYGDAAVWQQGARYQEAIAPHLGWWKQTLAGAPHLELPTQHPRPQVPSFRGARHVVRIPGDLLESVKALGRGEGASLFMTMLSVFGALLHRYSGAEDLVVGGAFSGRSREESQAISGHFVNLLPLRLRFSEGLTVRGLLEQVRRVCLEALEHQDAPLVRIVEAVNPARIPGANPLFQVSCTLEPRIAVPASDWRVEPHDVDTGTSKLDLSIELDERPDGMSVRWEYALDVFEPWMVHQLGQHFVTLLREASHDPEQLLSALPLLSEAEQSQVLAWAHGPAREVAHADCLHHPFEAQVERTPDAPALVFQGRPLSYRALDTEANRLAHHLISQGVRPGDFVGICVQRSFELIITLLAALKAGAAYVPLDPAYPRARLEFMARDAALRLILAQEATLALMDGMGVPVVALEQVRGGPEDAPRIHVTGDALAYVIYTSGSTGQPKGVCIGHRSAVHLTETVASDFGFAPGQRVAQCARYGFDFSVAEIFPTLSSGATLYLMGQEDVAAGAELADFLETHRIHTAMFTPSALASMPWRALPDLKTLAIGGEELPARLVDTWAPGRRFIQVYGPTEATVFTTTAECVAGDGPYPIGTPLPGYEVYLLDETLTPVPVGVRGALYIGGKGLAHGYLHRPELDAERFIPHPFSAEPGARLYKSGDIASHRPDGGIDFHGRSDRQLKLRGFRIELGEIEAALRQHPDVRDAVVEPRLIAGERHLVGYVIPRDAAVTPAFKESLGKTLPPHMIPREWVLLEAFPMGPTGKLDRNVLPLPSVKAPAAPESSVSTEREKALERIWCRILGVERVGRHEGFFDAGGSSLLLTRVQSALASELDIRVSMATLFQFPTLESLARHLDADSTVQPVTPEPTRSPVRSSDSIAIIGTAGRFPGAPSVEALWTLLVEGREGLSRFSRETLLAAGEDPQLLEDPSYVRASGLLEDVESFDAAFFGYSPLDARLMDPQLRMFLECAWEALEAAGYDPKRLPGKAGLFAGSGVPRYWLDQVMPRFRSLSVGSEAYRSILGNPWQFLATATAYQLGLRGPALTVQTACSTSLVAVHLACQSLRAGESDVALAGGISLFASGPSGYLHEAGGITSPDGHCRPFDAKGQGTVPSSGVGIVVLKRLEDALRDGDSIHAVIRGSAINNDGDAKVGFTAPSVEGQRDVITRAHADAGVAARDITYVEAHGTATPLGDPLEVQALRLAFGAREASEPAVVLGALKSNVGHLDSAAGVAGLIKTTLALEHRFLPGTVHFEQPHPEAGLERSPFVVSSEGRPWSLPEGFPRLAGVSAFGIGGTNAHVVLEEARPEPAVDVGPTVEVLVLSARSGEALSAASRRLADHLERHPEQSLADVAYTLQEGRTAFGYRRAIACETPGEAIAALRRDGPAQPAASPLPEVCFLFPGTGTQEAGMGAAWYRRAPAYREAFDACAALFGPELERDLRAALLTDERGAQAEEALRAPSLGMAAIFTTEYSLSRLLGAWGLHPTSLLGHSLGEYAAACLSGVLSLEQAVALVALRGRLCDALPPSGMLAVPLSEGVLTQELPPGLSLAAVNGPGQCVVSGALEALEDFAARLRERGVRTKRLPNASGFHSALVEPAMQPLTDLARSMRPKSPAIPLLSNVTGTWLTADDAHDRTYWARHLRHTVRFSQGLELLLEDRERIFVEVGPGQTLSTLTLLNPRAGRERLVLHTGRRHPPEGEEQALLQAVGQLWSAGLPVDWGAVRGSGPRRRVVLPTYPFERKRYSLAEKTPRPPRPEVTAAPRPLSREEVRASMEALWKELLGVDTLTPDSHFFQLGGTSLLVVQLNRELKTRLSVNLSLHAVLEHPTLGAWVRAVQDELERTGRPLTQAAPLRMALQEGRRGRTPLFLVQPIGGTVYTYLPLAKQLGADIPVHAFRASGLEPGEVLYRDVPAMARAYVDELLAFQPQGPFWLGGHSSGGVIAYEMAAELLKQGHSVAGVIQIDTVTVDDSRRLNVRSVGDVLQLVDAFQEISPRAAEGLRTAMEHDTRLRDVVLATNEAIAAYAPGRHAVPLVYLRASERDPVLDSHAAAWWKALTTASFQSHDVRGNHFTVMEEPHVAEVARLIRDTLTAGGERDDLDAG
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Reference