2026-10-24_00000434|hard|9YTB

RIPTAC in complex with BCL6 and BRD4; X-ray diffraction 2.29Å
Protein #1 126 residues (100% resolved)

SADSQIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKRNLSVINLDPEINPEGFNILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASE

SADSQIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKRNLSVINLDPEINPEGFNILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASE
Protein #2 127 residues (86% resolved)

SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE

SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
Non polymer #3 A1CY3

InChI=1S/C51H59ClN12O8S/c1-5-73(68,69)58-36-10-12-44(40(29-36)41-32-59(3)50(67)47-39(41)13-14-54-47)72-38-8-6-7-37(30-38)70-26-25-63-19-17-61(18-20-63)15-16-62-21-23-64(24-22-62)51-55-31-42(52)48(57-51)56-35-9-11-43-34(27-35)28-45(49(66)60(43)4)71-33-46(65)53-2/h6-14,27-32,54,58H,5,15-26,33H2,1-4H3,(H,53,65)(H,55,56,57)

CCS(=O)(=O)Nc1ccc(c(c1)C2=CN(C(=O)c3c2cc[nH]3)C)Oc4cccc(c4)OCCN5CCN(CC5)CCN6CCN(CC6)c7ncc(c(n7)Nc8ccc9c(c8)C=C(C(=O)N9C)OCC(=O)NC)Cl
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Reference