2026-10-24_00000415|medium|9XCT

Cryo-EM structure of SmcEWT, a peptidase-domain containing ABC Transporter, with ADP and vanadate; Electron microscopy 3.61Å
Protein #1 707 residues (75% resolved)

MLFSWQKTPLILQSETNECGLACLAMMAGYFGKRIDLASARTLHGIGSHGMTLRDLITAFERVGMTARASRVELDELRSLSRPAILHWSFNHFVVLVKVTRRGAVILDPAIGRRSISLRELSDKFTGVLVEAWPAETFDKKALEMNVTVSDLFRGVRGLRRIFTGVLMLSVLVELLSIAVPAASQFTIDTLVRSSDREGIFFVGIVVISALLIKSAFSVVRAWILMNLRYTLGVKWAEMFFNRLIKLTLSFFEKRHTGDIASRFQSLTAIQEAFTADMVASLLDAIVIVISMAIIFTYSPVLAIGPLIAACAYAALKAGLFSTYRNRKIEHIAFEAVQSSHFLETVRAIGAIKMLNLTPVRRREWVNHVVNSTHAGNQLFKLDLLTNTAAVLLVGFSGIFVLSVGAIGFDKGITTGALLAVMLYADMVITRTVKLVNAVSDFCLVSMHSQRLTDVAVSPVERDEGEQVSPQLNGHIVIRNLAFRHSQTERNIFEGINLEIMPGENVAIVGPSGCGKSTFLHVLAGLYESTEGDVFINNVGMSGMGKRDIREHVAFVMQDDKLLAGTIQQNITGFTASPDVERMAECANHAAIDEEISAFPQGYESMIGDIGSTLSGGQRQRISIARALYRQPRVLLLDEATSDLDIDNEKKITRAIGQLPITRIFVAHRPEMIKSADRVFNLHLNAWVKQENRGGATMLIADKVHIS

MLFSWQKTPLILQSETNECGLACLAMMAGYFGKRIDLASARTLHGIGSHGMTLRDLITAFERVGMTARASRVELDELRSLSRPAILHWSFNHFVVLVKVTRRGAVILDPAIGRRSISLRELSDKFTGVLVEAWPAETFDKKALEMNVTVSDLFRGVRGLRRIFTGVLMLSVLVELLSIAVPAASQFTIDTLVRSSDREGIFFVGIVVISALLIKSAFSVVRAWILMNLRYTLGVKWAEMFFNRLIKLTLSFFEKRHTGDIASRFQSLTAIQEAFTADMVASLLDAIVIVISMAIIFTYSPVLAIGPLIAACAYAALKAGLFSTYRNRKIEHIAFEAVQSSHFLETVRAIGAIKMLNLTPVRRREWVNHVVNSTHAGNQLFKLDLLTNTAAVLLVGFSGIFVLSVGAIGFDKGITTGALLAVMLYADMVITRTVKLVNAVSDFCLVSMHSQRLTDVAVSPVERDEGEQVSPQLNGHIVIRNLAFRHSQTERNIFEGINLEIMPGENVAIVGPSGCGKSTFLHVLAGLYESTEGDVFINNVGMSGMGKRDIREHVAFVMQDDKLLAGTIQQNITGFTASPDVERMAECANHAAIDEEISAFPQGYESMIGDIGSTLSGGQRQRISIARALYRQPRVLLLDEATSDLDIDNEKKITRAIGQLPITRIFVAHRPEMIKSADRVFNLHLNAWVKQENRGGATMLIADKVHIS
Non polymer #2 ADP

InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
Non polymer #3 AV0

InChI=1S/C47H88O22/c1-3-5-7-9-11-13-15-17-19-47(20-18-16-14-12-10-8-6-4-2,25-62-43-39(60)35(56)41(29(23-50)66-43)68-45-37(58)33(54)31(52)27(21-48)64-45)26-63-44-40(61)36(57)42(30(24-51)67-44)69-46-38(59)34(55)32(53)28(22-49)65-46/h27-46,48-61H,3-26H2,1-2H3/t27-,28-,29-,30-,31-,32-,33+,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m1/s1

CCCCCCCCCCC(CCCCCCCCCC)(CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O)CO[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O
Non polymer #4 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #5 VO4

InChI=1S/4O.V/q;3*-1;

[O-][V](=O)([O-])[O-]
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Reference