2026-10-24_00000376|ligand|9X8Y

Crystal structure of AfRIOK1 and the inhibitor CINS-1; X-ray diffraction 2.76Å
Protein #1 258 residues (94% resolved)

MKDLKKIESYLDKLRIKEKDGEERKIYAEVLDGRTLKTLYKLSAKGYITAMGGVISTGKEANVFYADGVFDGKPVAMAVKIYRIETSEFDKMDEYLYGDERFDMRRISPKEKVFIWTEKEFRNLERAKEAGVSVPQPYTYMKNVLLMEFIGEDELPAPTLVELGRELKELDVEGIFNDVVENVKRLYQEAELVHADLSEYNIMYIDKVYFIDMGQAVTLRHPMAESYLERDVRNIIRFFSKYGVKADFEEMLKEVKGE

MKDLKKIESYLDKLRIKEKDGEERKIYAEVLDGRTLKTLYKLSAKGYITAMGGVISTGKEANVFYADGVFDGKPVAMAVKIYRIETSEFDKMDEYLYGDERFDMRRISPKEKVFIWTEKEFRNLERAKEAGVSVPQPYTYMKNVLLMEFIGEDELPAPTLVELGRELKELDVEGIFNDVVENVKRLYQEAELVHADLSEYNIMYIDKVYFIDMGQAVTLRHPMAESYLERDVRNIIRFFSKYGVKADFEEMLKEVKGE
Non polymer #2 A1EZG

InChI=1S/C23H18N2O2/c24-15-21(14-17-8-12-22(26)13-9-17)23(27)25-16-18-6-10-20(11-7-18)19-4-2-1-3-5-19/h1-14,26H,16H2,(H,25,27)/b21-14-

c1ccc(cc1)c2ccc(cc2)CNC(=O)/C(=C\c3ccc(cc3)O)/C#N
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Reference