2026-10-24_00000371|medium|9X8O

Structure of Candida aurisglycosylphosphatidylinositol transamidase; Electron microscopy 3.19Å
Protein #1 812 residues (66% resolved)

MLWLIPFLLALALATSYKEELTFRPLPRNTLLADFHFNSVLPPFPLEYTNLSAPQSSHKPRHYGFFPRMLAPIVEATNTRELHLRFTQGWWDADLWGLLPHNGTVIGGTGVEVWAAIEAPSIEEAKRSWYKLTESLSGVFCASLNFVNDAITTVPKHKTASQGAGFVTSPGNKLFLLRAALPDEPICTENLTPFLKMLPTRGKAGIASLLDGHKLYDSLWHSMSVDLVTHCEDGQCHLELDQHIHHVADITRLIRRRNEGGIPKPVPGDKLRCDQSKYHDAWHCFPAPEFPAIEWDIEGLYGRAIQGPGFENQRGVTTVNFLVDKESWRVALTEEGKDDVPVENIFEIVEAKPHNFRISTADFNKVLPKQDSPLLVSRSLTGYSQDLGGMRVTIRNPQDKDLSLVYFESLPWFMRIYLHTLQVGGNGTVENQFFKPAIDRERPTHLELALSIPAGGSITLTYQFDKSLLLFSEYPPDANHGFAIEPAVVKIIDKETGNTLYQLRTPSLLLTLPTPDFSMPYNVTILTCTVMSLAFGCVFNLLVKKVVTEEEFEEISKKSPLGKLKAKIAMLKSKIKGVKAGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGS

MLWLIPFLLALALATSYKEELTFRPLPRNTLLADFHFNSVLPPFPLEYTNLSAPQSSHKPRHYGFFPRMLAPIVEATNTRELHLRFTQGWWDADLWGLLPHNGTVIGGTGVEVWAAIEAPSIEEAKRSWYKLTESLSGVFCASLNFVNDAITTVPKHKTASQGAGFVTSPGNKLFLLRAALPDEPICTENLTPFLKMLPTRGKAGIASLLDGHKLYDSLWHSMSVDLVTHCEDGQCHLELDQHIHHVADITRLIRRRNEGGIPKPVPGDKLRCDQSKYHDAWHCFPAPEFPAIEWDIEGLYGRAIQGPGFENQRGVTTVNFLVDKESWRVALTEEGKDDVPVENIFEIVEAKPHNFRISTADFNKVLPKQDSPLLVSRSLTGYSQDLGGMRVTIRNPQDKDLSLVYFESLPWFMRIYLHTLQVGGNGTVENQFFKPAIDRERPTHLELALSIPAGGSITLTYQFDKSLLLFSEYPPDANHGFAIEPAVVKIIDKETGNTLYQLRTPSLLLTLPTPDFSMPYNVTILTCTVMSLAFGCVFNLLVKKVVTEEEFEEISKKSPLGKLKAKIAMLKSKIKGVKAGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGS
Protein #2 834 residues (69% resolved)

MALAESFLRRVHESGIIPKIVKLLPIISFCFALGSIAWLLVLPLDGQYRNTYISENALMPGQVTSYFRESEWNIVRGYRSQAKKWDYEQAARSNPELGSWLSDLGLKVAHFDDPKTNSTTLYAVMHAPRGDNTEAIVLVTPYITSSDESNIGGFALAPALARYFGRMSIWSKNIIFVFPRDGHASLRSWVEAYHTSLDLTAGSIEAAIVLEYAMDSDNFDHMQLFYEGLNGQLPNLDLINTVTTIARNENMHVGIQGTPGEELTRRDYMSRIRTLARGIINLALAGLQKSSLGCEAFSGWQIQAITIRAVGTGGPDITQFGRIADSTFRAVNNLLEKFHQSFFFYLLLSPTHFVSIGTYLPSAVLLAIAFALSSLCCLANGVNGRAYLAGMGTLLTTFTGVELISLILAFTLPHLVKISEDPQVRSQIIIAVAILLTLELSTKQVIGRIVTIRFSKVTTYSLIAFSLYFIAMLVTALLIVHFALALMIGLCSLPLTFIQPQITEQLKKKGSCIKTHFRIVLCLLFSSPVTAVVFSGYLLDGGPDGVATLTHRLLTSWDELSCWTWFVVVLGWFPAWVSIALAYTFGTFEDVQANGNDNEKSEGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGS

MALAESFLRRVHESGIIPKIVKLLPIISFCFALGSIAWLLVLPLDGQYRNTYISENALMPGQVTSYFRESEWNIVRGYRSQAKKWDYEQAARSNPELGSWLSDLGLKVAHFDDPKTNSTTLYAVMHAPRGDNTEAIVLVTPYITSSDESNIGGFALAPALARYFGRMSIWSKNIIFVFPRDGHASLRSWVEAYHTSLDLTAGSIEAAIVLEYAMDSDNFDHMQLFYEGLNGQLPNLDLINTVTTIARNENMHVGIQGTPGEELTRRDYMSRIRTLARGIINLALAGLQKSSLGCEAFSGWQIQAITIRAVGTGGPDITQFGRIADSTFRAVNNLLEKFHQSFFFYLLLSPTHFVSIGTYLPSAVLLAIAFALSSLCCLANGVNGRAYLAGMGTLLTTFTGVELISLILAFTLPHLVKISEDPQVRSQIIIAVAILLTLELSTKQVIGRIVTIRFSKVTTYSLIAFSLYFIAMLVTALLIVHFALALMIGLCSLPLTFIQPQITEQLKKKGSCIKTHFRIVLCLLFSSPVTAVVFSGYLLDGGPDGVATLTHRLLTSWDELSCWTWFVVVLGWFPAWVSIALAYTFGTFEDVQANGNDNEKSEGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGS
Protein #3 658 residues (65% resolved)

MSLAAVLAIGTLIRVVVPSLFPRITDALASTVETSTPIDSFRSIQEAFYLLKNDLDVYDGGVVYHPPLLVSLLNLVNDAFPENYVFIVFNILYAIVDLGIACKLIRANQWYDEHQRKRSKIEGLPFSSTFIAAFYLFNPLMILTNWSHSTAVFSYFLIIELVVQVVVDHNPFRAMIALAVGAYLSLTPGFLVVPVIALAFTVSADRDYTRLAVQCSAIFIASMATLLLLSFILSGTPDFFYQCYGNILFFDKFSPNMGLWWYIFTEMFDFFTPLYKGIFNLYHVIFVVPITVRFFERESEPQIGDSFLAVVMAHTWLSFSKSYPIIGDLGFVLSMLPIFKNTVIPHTKFMLINALTLIICLLLAPIFYYCWIVLGNGNSNFFFSMSLIWGGVYIVIFLDFIWGRLVFDYIQTNEVKDRKALRLTQIGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGS

MSLAAVLAIGTLIRVVVPSLFPRITDALASTVETSTPIDSFRSIQEAFYLLKNDLDVYDGGVVYHPPLLVSLLNLVNDAFPENYVFIVFNILYAIVDLGIACKLIRANQWYDEHQRKRSKIEGLPFSSTFIAAFYLFNPLMILTNWSHSTAVFSYFLIIELVVQVVVDHNPFRAMIALAVGAYLSLTPGFLVVPVIALAFTVSADRDYTRLAVQCSAIFIASMATLLLLSFILSGTPDFFYQCYGNILFFDKFSPNMGLWWYIFTEMFDFFTPLYKGIFNLYHVIFVVPITVRFFERESEPQIGDSFLAVVMAHTWLSFSKSYPIIGDLGFVLSMLPIFKNTVIPHTKFMLINALTLIICLLLAPIFYYCWIVLGNGNSNFFFSMSLIWGGVYIVIFLDFIWGRLVFDYIQTNEVKDRKALRLTQIGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGS
Protein #4 733 residues (64% resolved)

MKRSQESESTKWTRRLVVWVISAFVVFLGAPMFFYTTSIHRAALPVEELMHRRNNFSEAIAIQVPLYIQCEESLDVDSLQRQIDNVIKSEWGVDNSWRVNLKLASEHTPDPLKDYIVDIVIDGDKKPSMMPNTLMSTVHANCKDCVSKKLLEVLELIFKNEVDTILDVIHRRVSKVEHNEVAVPHSSTYNLVFNLFVEDGRAVDWEIDDAVSSIQPLLDLLKHYTSFKITSQVQYYSKLHNPTLFDNETNRYIIPTKDLSTFINYGDWNLIIHDVYPTINFIVFFPAANHKGYPLMLENSKTNSFIVPQWGGVYIYNSEMPVLDDYTYTLHQEKLAPIFDIFAYQLLELMGVPKDPKSLLMRVASFHRIMAMKNLKHLIENLSSLVTLSNSLDEISIPESTFAHMVDSLDFFDKAVECLKTGLFDSAMEYSSKGLISSDKAFFEKEMVQQAYFPSEHKLAVFLPLLGPLGAIVIFGLIGSLKEQAKEKREKKKELENKKKSGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGS

MKRSQESESTKWTRRLVVWVISAFVVFLGAPMFFYTTSIHRAALPVEELMHRRNNFSEAIAIQVPLYIQCEESLDVDSLQRQIDNVIKSEWGVDNSWRVNLKLASEHTPDPLKDYIVDIVIDGDKKPSMMPNTLMSTVHANCKDCVSKKLLEVLELIFKNEVDTILDVIHRRVSKVEHNEVAVPHSSTYNLVFNLFVEDGRAVDWEIDDAVSSIQPLLDLLKHYTSFKITSQVQYYSKLHNPTLFDNETNRYIIPTKDLSTFINYGDWNLIIHDVYPTINFIVFFPAANHKGYPLMLENSKTNSFIVPQWGGVYIYNSEMPVLDDYTYTLHQEKLAPIFDIFAYQLLELMGVPKDPKSLLMRVASFHRIMAMKNLKHLIENLSSLVTLSNSLDEISIPESTFAHMVDSLDFFDKAVECLKTGLFDSAMEYSSKGLISSDKAFFEKEMVQQAYFPSEHKLAVFLPLLGPLGAIVIFGLIGSLKEQAKEKREKKKELENKKKSGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGS
Protein #5 659 residues (47% resolved)

MRILQVCHIIIAALLSTAWASDSSDGSQIVTVDDAAKIIHTTTSTHTNNWAVLVSTSRFWFNYRHMANTLSLYRTVKRMGIPDSQIILMLADDIACNPRNAFPGTVFNNMDQAIDLYGDDVEVDYRGYEVTVENFIRLLTDRWDENHPRSKRLLTDENSNIFIYLTGHGGNEFLKFQDAEEIGSWDLAHAFQQMYSKKRYNEIFFMIDTCQANTMYEKIYSPNVLAVGSSRIDESSYSHHSDLDVGVAVIDRFTYYTLDFLEKIEKNSNVTMDKLFAEYTFENVHSNPGIRTDLFPRALNEVLLTDFFGNVQDVILDDVEQGILDYNRSIPITSSSKDDSSDSQVIEASFSDEDYHTKQLHHVSQREAKVITAVSIVALCLLWTFAKPGTGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGSAGSLEVLFQGPLGSDYKDDDDKLENSAVDHHHHHHHH

MRILQVCHIIIAALLSTAWASDSSDGSQIVTVDDAAKIIHTTTSTHTNNWAVLVSTSRFWFNYRHMANTLSLYRTVKRMGIPDSQIILMLADDIACNPRNAFPGTVFNNMDQAIDLYGDDVEVDYRGYEVTVENFIRLLTDRWDENHPRSKRLLTDENSNIFIYLTGHGGNEFLKFQDAEEIGSWDLAHAFQQMYSKKRYNEIFFMIDTCQANTMYEKIYSPNVLAVGSSRIDESSYSHHSDLDVGVAVIDRFTYYTLDFLEKIEKNSNVTMDKLFAEYTFENVHSNPGIRTDLFPRALNEVLLTDFFGNVQDVILDDVEQGILDYNRSIPITSSSKDDSSDSQVIEASFSDEDYHTKQLHHVSQREAKVITAVSIVALCLLWTFAKPGTGGSGGSASVIKPEMKIKLRMEGAVNGHKFVIEGEGIGKPYEGTQTLDLTVEEGAPLPFSYDILTPAFQYGNRAFTKYPEDIPDYFKQAFPEGYSWERSMTYEDQGICIATSDITMEGDCFFYEIRFDGTNFPPNGPVMQKKTLKWEPSTEKMYVEDGVLKGDVEMALLLEGGGHYRCDFKTTYKAKKDVRLPDAHEVDHRIEILSHDKDYNKVRLYEHAEARYSGGGSGGGSAGSLEVLFQGPLGSDYKDDDDKLENSAVDHHHHHHHH
Non polymer #6 A1EZD

InChI=1S/C41H76N2O26P2/c1-4-7-9-11-14-25(46)59-20-22(62-26(47)13-6-3)21-61-71(57,58)69-39-36(65-27(48)15-12-10-8-5-2)33(53)31(51)34(54)37(39)67-40-28(43)30(50)35(24(19-45)64-40)66-41-38(68-70(55,56)60-17-16-42)32(52)29(49)23(18-44)63-41/h22-24,28-41,44-45,49-54H,4-21,42-43H2,1-3H3,(H,55,56)(H,57,58)/t22-,23-,24-,28-,29-,30-,31+,32+,33+,34-,35+,36-,37+,38+,39+,40-,41-/m1/s1

CCCCCCC(=O)OC[C@H](COP(=O)(O)O[C@@H]1[C@H]([C@@H]([C@H]([C@@H]([C@H]1OC(=O)CCCCCC)O)O)O)O[C@@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3[C@H]([C@H]([C@@H]([C@H](O3)CO)O)O)OP(=O)(O)OCCN)O)N)OC(=O)CCC
Non polymer #7 C14

InChI=1S/C14H30/c1-3-5-7-9-11-13-14-12-10-8-6-4-2/h3-14H2,1-2H3

CCCCCCCCCCCCCC
Non polymer #8 CA

InChI=1S/Ca/q+2

[Ca+2]
Non polymer #9 CLR

InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
Non polymer #10 D12

InChI=1S/C12H26/c1-3-5-7-9-11-12-10-8-6-4-2/h3-12H2,1-2H3

CCCCCCCCCCCC
Non polymer #11 DD9

InChI=1S/C9H20/c1-3-5-7-9-8-6-4-2/h3-9H2,1-2H3

CCCCCCCCC
Non polymer #12 HP6

InChI=1S/C7H16/c1-3-5-7-6-4-2/h3-7H2,1-2H3

CCCCCCC
Non polymer #13 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
Non polymer #14 XKP

InChI=1S/C23H46NO8P/c1-3-5-7-9-10-12-14-16-23(26)32-21(20-31-33(27,28)30-18-17-24)19-29-22(25)15-13-11-8-6-4-2/h21H,3-20,24H2,1-2H3,(H,27,28)/t21-/m1/s1

CCCCCCCCCC(=O)O[C@H](COC(=O)CCCCCCC)COP(=O)(O)OCCN
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