2026-10-24_00000238|ligand|9SYO

Crystal structure of human Hsp90-alpha NBD(aa9-236)in complex with dual chaperon targeting ligand THOR-1; X-ray diffraction 1.29Å
Protein #1 228 residues (92% resolved)

DQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAE

DQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAE
Non polymer #2 A1JR1

InChI=1S/C16H14N2O3S/c19-12-6-11(7-13(20)8-12)17-15(21)9-22-16-5-10-3-1-2-4-14(10)18-16/h1-8,18-20H,9H2,(H,17,21)

c1ccc2c(c1)cc([nH]2)SCC(=O)Nc3cc(cc(c3)O)O
Non polymer #3 MG

InChI=1S/Mg/q+2

[Mg+2]
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Reference