2026-10-24_00000237|ligand|9SYM

Structure of human DNMT2 with bound competitive inhibitor; X-ray diffraction 2.00Å
Protein #1 348 residues (93% resolved)

GAMEPLRVLELYSGVGGMHHALRES(CME)IPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIEN(CME)GFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSV(CME)FTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE

GAMEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE
Non polymer #2 A1JR0

InChI=1S/C21H30N10O6/c22-11(20(34)35)3-5-30(4-1-2-10-6-25-21(36)29-16(10)23)7-12-14(32)15(33)19(37-12)31-9-28-13-17(24)26-8-27-18(13)31/h6,8-9,11-12,14-15,19,32-33H,1-5,7,22H2,(H,34,35)(H2,24,26,27)(H3,23,25,29,36)/t11-,12+,14+,15+,19+/m0/s1

c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CN(CCCC4=CNC(=O)N=C4N)CC[C@@H](C(=O)O)N)O)O)N
Non polymer #3 EDO

InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

C(CO)O
Non polymer #4 GLY

InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

C(C(=O)O)N
Download coordinates
Reference