2026-10-24_00000235|ligand|9SYK

Structure of human DNMT2 with bound competitive inhibitor; X-ray diffraction 1.80Å
Protein #1 348 residues (91% resolved)

GAMEPLRVLELYSGVGGMHHALRES(CME)IPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPP(CSO)QPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPT(CSO)RRSV(CSO)FTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE

GAMEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE
Non polymer #2 A1JRY

InChI=1S/C22H25F3N8O7/c23-22(24,25)11-5-10(1-2-13(11)33(38)39)6-31(4-3-12(26)21(36)37)7-14-16(34)17(35)20(40-14)32-9-30-15-18(27)28-8-29-19(15)32/h1-2,5,8-9,12,14,16-17,20,34-35H,3-4,6-7,26H2,(H,36,37)(H2,27,28,29)/t12-,14+,16+,17+,20+/m0/s1

c1cc(c(cc1CN(CC[C@@H](C(=O)O)N)C[C@@H]2[C@H]([C@H]([C@@H](O2)n3cnc4c3ncnc4N)O)O)C(F)(F)F)[N+](=O)[O-]
Non polymer #3 EDO

InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

C(CO)O
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Reference