2026-10-24_00000231|hard|9SWZ

Structure of MM762(D10A)-sgRNA/DNA ternary complex; Electron microscopy 3.02Å
Protein #1 762 residues (87% resolved)

MEKELVLGIAYGGKYTGLAVVNQKNNQVLYARTVKMRDDVTDILAGRREQRSLRRTLQTKKKRLRELKNYLESIGGIYEESSGTFTIEPFRTVYSLAHKRGYDYADLPEEKTSEEIEAMDAKERKQWEKEKKELEETQRNSRHRDEVLRDVRNVMTEGNLSEEQIIKVESIFNKQYRHKRFNNRILTKCKVCGKNTPLRINVRELLLENIVRYLPLQNKERELLKLTILKGHQQDINEIFKHFRKVYKITLNQKDWPGKNLIDIARNQLRGRLLFCKVHFPENEKYVSIEKKTFRLAPSLKTKIENVLSVIKDDILPNFTLNNVVMESNNFDIAAKTKGKKRLLKEEYSKGHRESGETRKEALLRETDSRCIYCGKGIDLSNAHEDHIFPRKAGGINIFGNLVACCSVCNEEKRGRTPLESGILPKPEIVSFITNDLKKKILEDAQYINTLDFNKYMSHASIGWRHMRDRLRELTGNKELLIKRQSGIYTAYFRKWWGFIKERGNHGHHALDAVILASKKSYAEDGKVDMTIKPCGEDGKEFDIERHLSEMKEFRRDKGGKSAPLHDRNPLSFKNDIITRRFMVTEIECGKEAVIISEEYRKKLTEAFKRFGIAKGKYLTDEQAKDAGFYLRKNGEGVMSLKCEVKGTGYNQMIRIKNNIFKTNVHNVGVAVFLDEKGKKRACELKNPRLSKHFVKPAEQVKGKVIFILKRGNMVTVEGEEMIYRVKKLGTSPVIEAIVGSDGKTRTVSATKLLKINHTKKV

MEKELVLGIAYGGKYTGLAVVNQKNNQVLYARTVKMRDDVTDILAGRREQRSLRRTLQTKKKRLRELKNYLESIGGIYEESSGTFTIEPFRTVYSLAHKRGYDYADLPEEKTSEEIEAMDAKERKQWEKEKKELEETQRNSRHRDEVLRDVRNVMTEGNLSEEQIIKVESIFNKQYRHKRFNNRILTKCKVCGKNTPLRINVRELLLENIVRYLPLQNKERELLKLTILKGHQQDINEIFKHFRKVYKITLNQKDWPGKNLIDIARNQLRGRLLFCKVHFPENEKYVSIEKKTFRLAPSLKTKIENVLSVIKDDILPNFTLNNVVMESNNFDIAAKTKGKKRLLKEEYSKGHRESGETRKEALLRETDSRCIYCGKGIDLSNAHEDHIFPRKAGGINIFGNLVACCSVCNEEKRGRTPLESGILPKPEIVSFITNDLKKKILEDAQYINTLDFNKYMSHASIGWRHMRDRLRELTGNKELLIKRQSGIYTAYFRKWWGFIKERGNHGHHALDAVILASKKSYAEDGKVDMTIKPCGEDGKEFDIERHLSEMKEFRRDKGGKSAPLHDRNPLSFKNDIITRRFMVTEIECGKEAVIISEEYRKKLTEAFKRFGIAKGKYLTDEQAKDAGFYLRKNGEGVMSLKCEVKGTGYNQMIRIKNNIFKTNVHNVGVAVFLDEKGKKRACELKNPRLSKHFVKPAEQVKGKVIFILKRGNMVTVEGEEMIYRVKKLGTSPVIEAIVGSDGKTRTVSATKLLKINHTKKV
RNA #2 131 bases

CGAAAACUAACUGUUACAGUUAAGGCUGCCUUAAUUGUAAAACGCCUAUACGGUGAGGGUAUGUACGUUUGGGUUUGUCCAGCCUAAACCUCUACGCCAGAAAUGGCACCUUCAUUGUGGGUUAGGACAAU

CGAAAACUAACUGUUACAGUUAAGGCUGCCUUAAUUGUAAAACGCCUAUACGGUGAGGGUAUGUACGUUUGGGUUUGUCCAGCCUAAACCUCUACGCCAGAAAUGGCACCUUCAUUGUGGGUUAGGACAAU
DNA #3 35 bases

(DG)(DG)(DT)(DA)(DA)(DG)(DG)(DA)(DG)(DA)(DA)(DC)(DG)(DG)(DC)(DG)(DA)(DA)(DA)(DA)(DC)(DT)(DA)(DA)(DC)(DT)(DT)(DG)(DG)(DA)(DA)(DT)(DT)(DT)(DG)

GGTAAGGAGAACGGCGAAAACTAACTTGGAATTTG
DNA #4 20 bases

(DC)(DA)(DA)(DA)(DT)(DT)(DC)(DC)(DA)(DA)(DG)(DT)(DT)(DA)(DG)(DT)(DT)(DT)(DA)(DA)

CAAATTCCAAGTTAGTTTAA
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Reference