2026-10-24_00000202|ligand|9PWI

EGFR kinase bound to ZNL-1; X-ray diffraction 2.60Å
Protein #1 331 residues (83% resolved)

GSTSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG

GSTSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG
Non polymer #2 A1CMF

InChI=1S/C28H32N8O2/c1-4-25(37)31-24-8-6-5-7-20(24)18-36-19-21-17-29-27(32-26(21)34(3)28(36)38)30-22-9-11-23(12-10-22)35-15-13-33(2)14-16-35/h4-12,17H,1,13-16,18-19H2,2-3H3,(H,31,37)(H,29,30,32)

CN1CCN(CC1)c2ccc(cc2)Nc3ncc4c(n3)N(C(=O)N(C4)Cc5ccccc5NC(=O)C=C)C
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Reference