2026-10-17_00000169|ligand|9SXX

Crystal structure of ERK2 in complex with a ligand; X-ray diffraction 1.74Å
Protein #1 364 residues (94% resolved)

HHHHHHMAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT(CME)DLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS

HHHHHHMAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Non polymer #2 A1JRR

InChI=1S/C22H18N6OS/c23-20(13-4-2-1-3-5-13)22(29)26-19-9-18(27-28-19)17-11-25-21-16(17)8-15(10-24-21)14-6-7-30-12-14/h1-12,20H,23H2,(H,24,25)(H2,26,27,28,29)/t20-/m0/s1

c1ccc(cc1)[C@@H](C(=O)Nc2cc([nH]n2)c3c[nH]c4c3cc(cn4)c5ccsc5)N
Non polymer #3 BME

InChI=1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2

C(CS)O
Download coordinates
Reference