2026-10-17_00000156|ligand|9SXF

c-KIT kinase domain in complex with (R)-Pyrrolidine derivative of AZD7762; X-ray diffraction 2.10Å
Protein #1 327 residues (90% resolved)

GSMPMYEVQWKVVEESNGNNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEKQISESTNH

GSMPMYEVQWKVVEESNGNNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEKQISESTNH
Non polymer #2 A1JRG

InChI=1S/C16H17FN4O2S/c17-10-3-1-2-9(6-10)13-7-12(21-16(18)23)14(24-13)15(22)20-11-4-5-19-8-11/h1-3,6-7,11,19H,4-5,8H2,(H,20,22)(H3,18,21,23)/t11-/m1/s1

c1cc(cc(c1)F)c2cc(c(s2)C(=O)N[C@@H]3CCNC3)NC(=O)N
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Reference