2026-10-17_00000115|ligand|34CO

Homo sapiens Eukaryotic translation initiation factor 4E (eIF4E) in complex with synthetic mRNA cap analogs; X-ray diffraction 2.00Å

Protein #1 193 residues (96% resolved)

Raw Sequence ...

GPMVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

Canonical Sequence ...

GPMVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

Non polymer #2 A1KQY

InChI=1S/C31H44N15O22P4/c1-43-12-44(25-17(43)27(50)42-31(34)40-25)3-4-60-5-6-61-70(53,54)67-72(57,58)68-71(55,56)63-8-14-20(21(59-2)29(65-14)45-10-37-15-22(32)35-9-36-23(15)45)66-69(51,52)62-7-13-18(47)19(48)28(64-13)46-11-38-16-24(46)39-30(33)41-26(16)49/h9-14,18-21,28-29,47-48H,3-8H2,1-2H3,(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H2,32,35,36)(H3,33,39,41,49)(H3,34,40,42,50)/t13?,14-,18?,19?,20-,21-,28?,29-/m1/s1

InChI=1S/C31H44N15O22P4/c1-43-12-44(25-17(43)27(50)42-31(34)40-25)3-4-60-5-6-61-70(53,54)67-72(57,58)68-71(55,56)63-8-14-20(21(59-2)29(65-14)45-10-37-15-22(32)35-9-36-23(15)45)66-69(51,52)62-7-13-18(47)19(48)28(64-13)46-11-38-16-24(46)39-30(33)41-26(16)49/h9-14,18-21,28-29,47-48H,3-8H2,1-2H3,(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H2,32,35,36)(H3,33,39,41,49)(H3,34,40,42,50)/t13?,14-,18?,19?,20-,21-,28?,29-/m1/s1

SMILES: C[N]1=CN(C2=C1C(=O)N=C(N2)N)CCOCCOP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)n4cnc5c4ncnc5N)OC)OP(=O)(O)OCC6C(C(C(O6)n7cnc8c7N=C(NC8=O)N)O)O

C[N]1=CN(C2=C1C(=O)N=C(N2)N)CCOCCOP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)n4cnc5c4ncnc5N)OC)OP(=O)(O)OCC6C(C(C(O6)n7cnc8c7N=C(NC8=O)N)O)O

Biounit #1 monomer

Biounit #2 monomer

Biounit #3 monomer

Biounit #4 monomer

Reference