2026-10-10_00000203|medium|9Y8G

Acetyl-CoA Synthetase(Acs1), Wild-type with Bound Acetyl-AMP from Syntrophous aciditrophicus.; X-ray diffraction 2.20Å
Protein #1 670 residues (97% resolved)

MGSMGEESILKEFYPVPERIKAKAWVKGRGEYDKLYAESIADSAAWWAKQADEILTFYKKWDKVEDFNFDIRKGPIHVKYFEGAKLNVSYNCLDRHLATKGDKVAIQWEGNEPGEQKAYTYKDLHTEVCKFANVLKKHGIKRGDRVCIYTPMVVEAAIAMLACTRIGAVHAIVFGGFSSDALAVRIQDAQAKLLVVCDGTFRGAKAVPQKKDADVALKECPTIEKVIVVRRVGDKIACDMTPGRDLWWHDEMATVDANCECEQMDAEDTLFILYTSGSTGQPKGALHTTAGYLLYAAYTSKFAFDLHDEDIHWCTADIGWVTGHSYVVYGPLALGATSIMFEGVPNYPTYSRFWQVVEKYKVTSFYTAPTAIRAIAKEGDEWLKGIDLSSLRVLSSVGEPLNPEAWQWFYEKIGNSQCPIVDTWWQTETGGHMILPLPGAIDIKPAKPALPIMGVIPTLVDDQTGEELKNMEANGALCFKTAWPGITRTIYGDHKRYEETYFEPYPGNYFSGDGALRDKDGYYRITGRIDDVINVSGHRMGTAEIEATLNAHEKVAESAVVGYPHEVKGQSIYAYITLKTGFEPSEDLKKELTQYVRTIIGPIATPEKIQWADGLPKTRSGKIMRRILKKVAANELGDLGDTSTLADPAVVDDLVKNRLLQPKLHHHHHH

MGSMGEESILKEFYPVPERIKAKAWVKGRGEYDKLYAESIADSAAWWAKQADEILTFYKKWDKVEDFNFDIRKGPIHVKYFEGAKLNVSYNCLDRHLATKGDKVAIQWEGNEPGEQKAYTYKDLHTEVCKFANVLKKHGIKRGDRVCIYTPMVVEAAIAMLACTRIGAVHAIVFGGFSSDALAVRIQDAQAKLLVVCDGTFRGAKAVPQKKDADVALKECPTIEKVIVVRRVGDKIACDMTPGRDLWWHDEMATVDANCECEQMDAEDTLFILYTSGSTGQPKGALHTTAGYLLYAAYTSKFAFDLHDEDIHWCTADIGWVTGHSYVVYGPLALGATSIMFEGVPNYPTYSRFWQVVEKYKVTSFYTAPTAIRAIAKEGDEWLKGIDLSSLRVLSSVGEPLNPEAWQWFYEKIGNSQCPIVDTWWQTETGGHMILPLPGAIDIKPAKPALPIMGVIPTLVDDQTGEELKNMEANGALCFKTAWPGITRTIYGDHKRYEETYFEPYPGNYFSGDGALRDKDGYYRITGRIDDVINVSGHRMGTAEIEATLNAHEKVAESAVVGYPHEVKGQSIYAYITLKTGFEPSEDLKKELTQYVRTIIGPIATPEKIQWADGLPKTRSGKIMRRILKKVAANELGDLGDTSTLADPAVVDDLVKNRLLQPKLHHHHHH
Non polymer #2 6R9

InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1

CC(=O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
Non polymer #3 NA

InChI=1S/Na/q+1

[Na+]
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Reference