2026-10-10_00000201|ligand|9XYH

Human mitochondrial ClpP in complex with OICR-18704 in the heptameric state; Electron microscopy 3.40Å
Protein #1 221 residues (76% resolved)

SLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST

SLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST
Non polymer #2 A1CRQ

InChI=1S/C24H20ClF3N6O/c1-15(12-29)34-22(31-21-10-17(25)3-5-19(21)23(34)35)14-32-6-8-33(9-7-32)18-4-2-16(13-30)20(11-18)24(26,27)28/h2-5,10-11,15H,6-9,14H2,1H3/t15-/m0/s1

C[C@@H](C#N)N1C(=Nc2cc(ccc2C1=O)Cl)CN3CCN(CC3)c4ccc(c(c4)C(F)(F)F)C#N
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