2026-10-10_00000147|hard|9R2Y

Drosophila MSL HAT nucleosome complex H4K16ac postcatalytic H3K36me3 reader state; Electron microscopy 3.40Å
Protein #1 135 residues (73% resolved)

ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGV(M3L)KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein #2 102 residues (87% resolved)

SGRGKGGKGLGKGGA(ALY)RHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

SGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Protein #3 129 residues (84% resolved)

SGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK

SGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK
Protein #4 125 residues (76% resolved)

PEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

PEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
DNA #5 225 bases

(DG)(DG)(DA)(DC)(DC)(DC)(DT)(DA)(DT)(DA)(DC)(DG)(DC)(DG)(DG)(DC)(DC)(DG)(DC)(DC)(DA)(DA)(DG)(DA)(DA)(DC)(DA)(DC)(DG)(DG)(DT)(DT)(DT)(DA)(DG)(DA)(DA)(DA)(DG)(DA)(DG)(DA)(DT)(DA)(DG)(DT)(DA)(DT)(DT)(DA)(DC)(DA)(DC)(DC)(DT)(DG)(DG)(DA)(DG)(DA)(DA)(DT)(DC)(DC)(DC)(DG)(DG)(DT)(DG)(DC)(DC)(DG)(DA)(DG)(DG)(DC)(DC)(DG)(DC)(DT)(DC)(DA)(DA)(DT)(DT)(DG)(DG)(DT)(DC)(DG)(DT)(DA)(DG)(DC)(DA)(DA)(DG)(DC)(DT)(DC)(DT)(DA)(DG)(DC)(DA)(DC)(DC)(DG)(DC)(DT)(DT)(DA)(DA)(DA)(DC)(DG)(DC)(DA)(DC)(DG)(DT)(DA)(DC)(DG)(DC)(DG)(DC)(DT)(DG)(DT)(DC)(DC)(DC)(DC)(DC)(DG)(DC)(DG)(DT)(DT)(DT)(DT)(DA)(DA)(DC)(DC)(DG)(DC)(DC)(DA)(DA)(DG)(DG)(DG)(DG)(DA)(DT)(DT)(DA)(DC)(DT)(DC)(DC)(DC)(DT)(DA)(DG)(DT)(DC)(DT)(DC)(DC)(DA)(DG)(DG)(DC)(DA)(DC)(DG)(DT)(DG)(DT)(DC)(DA)(DG)(DA)(DT)(DA)(DT)(DA)(DT)(DA)(DC)(DA)(DT)(DC)(DC)(DT)(DG)(DT)(DG)(DC)(DA)(DT)(DG)(DT)(DA)(DT)(DT)(DG)(DA)(DA)(DC)(DA)(DG)(DC)(DG)(DA)(DC)(DC)(DT)(DT)(DG)(DC)(DC)

GGACCCTATACGCGGCCGCCAAGAACACGGTTTAGAAAGAGATAGTATTACACCTGGAGAATCCCGGTGCCGAGGCCGCTCAATTGGTCGTAGCAAGCTCTAGCACCGCTTAAACGCACGTACGCGCTGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCAGGCACGTGTCAGATATATACATCCTGTGCATGTATTGAACAGCGACCTTGCC
DNA #6 225 bases

(DG)(DG)(DC)(DA)(DA)(DG)(DG)(DT)(DC)(DG)(DC)(DT)(DG)(DT)(DT)(DC)(DA)(DA)(DT)(DA)(DC)(DA)(DT)(DG)(DC)(DA)(DC)(DA)(DG)(DG)(DA)(DT)(DG)(DT)(DA)(DT)(DA)(DT)(DA)(DT)(DC)(DT)(DG)(DA)(DC)(DA)(DC)(DG)(DT)(DG)(DC)(DC)(DT)(DG)(DG)(DA)(DG)(DA)(DC)(DT)(DA)(DG)(DG)(DG)(DA)(DG)(DT)(DA)(DA)(DT)(DC)(DC)(DC)(DC)(DT)(DT)(DG)(DG)(DC)(DG)(DG)(DT)(DT)(DA)(DA)(DA)(DA)(DC)(DG)(DC)(DG)(DG)(DG)(DG)(DG)(DA)(DC)(DA)(DG)(DC)(DG)(DC)(DG)(DT)(DA)(DC)(DG)(DT)(DG)(DC)(DG)(DT)(DT)(DT)(DA)(DA)(DG)(DC)(DG)(DG)(DT)(DG)(DC)(DT)(DA)(DG)(DA)(DG)(DC)(DT)(DT)(DG)(DC)(DT)(DA)(DC)(DG)(DA)(DC)(DC)(DA)(DA)(DT)(DT)(DG)(DA)(DG)(DC)(DG)(DG)(DC)(DC)(DT)(DC)(DG)(DG)(DC)(DA)(DC)(DC)(DG)(DG)(DG)(DA)(DT)(DT)(DC)(DT)(DC)(DC)(DA)(DG)(DG)(DT)(DG)(DT)(DA)(DA)(DT)(DA)(DC)(DT)(DA)(DT)(DC)(DT)(DC)(DT)(DT)(DT)(DC)(DT)(DA)(DA)(DA)(DC)(DC)(DG)(DT)(DG)(DT)(DT)(DC)(DT)(DT)(DG)(DG)(DC)(DG)(DG)(DC)(DC)(DG)(DC)(DG)(DT)(DA)(DT)(DA)(DG)(DG)(DG)(DT)(DC)(DC)

GGCAAGGTCGCTGTTCAATACATGCACAGGATGTATATATCTGACACGTGCCTGGAGACTAGGGAGTAATCCCCTTGGCGGTTAAAACGCGGGGGACAGCGCGTACGTGCGTTTAAGCGGTGCTAGAGCTTGCTACGACCAATTGAGCGGCCTCGGCACCGGGATTCTCCAGGTGTAATACTATCTCTTTCTAAACCGTGTTCTTGGCGGCCGCGTATAGGGTCC
Protein #7 1047 residues (17% resolved)

MDKRFKWPPKKRANYLESPYPHIPSRGRQRNLHGHPNQTQHLHQHPGKIYERQQYGNGRGGHGGGNNNYRKLLHSLPAEHGGGAMAPPSSGGTVCAGADMVKLISENNNLRRMVMLNLNLMQEQTDSIAAKDKELDDQSAKMSVVKAQNEELKQAVAQLEAANQELCKQLRRKNQRRNDNDDDDDDPPLPPAAPQQKLIRCHAETQTVFREREQGTQTIDAQPQFANALPRGINMKESPALDHHAGAVTNQPASKRSESKGRGEFNGKKVSTFILQRMNQDFEHHIHEQTEVAEEHEMEAHKEQISQEEDQLVAEEDHLHMQEVHTEEVVGGDIFHDALESIEMEVVTEELVDMEEHGQSVDANGHIEEDDDEDDEDDENSDKDDDSEEDDYPWMHSDADVNARTEEELWQNQNYLLELDPTEEKTCAPSAHSTPNHQQKSSTQAEIRKEGNQNRITEKLLQLKPEPMVDALEAPILPKWVAFKKKDKEHESVPESPEVPKQQPHQEDAIVDHNAIKNQLEVPKPDLKPKDQPKDEQRQDGQLDVRVEPQEDVRKVQKETLKRQPEDAPKHLPKAVAPKVTKTSSRESTLPKANTADIKDAPAQKVIANHQSTKTQTDPVKTQRLQVKIRQYEMHPDMRTGSSAPSDIRKQKNVDPVSTPETKTIKSKSMLVNDKKTTSETSQSPDQEIDVETVRRKLAEHLKKELLSQSHSSQVTLKKIRERVATNLIYPPPSAPVSSTTITPAPTPSTTPTPGSTPQHAVTSSMDQEISAAKSKSKAAEQIATPLTPQSNSSVSSTTSTIRKTLNNCSPHTYSKATARSGKLQSRFRTATFPYSTRTWEDQEFHCDNEFFLEEADELLADNPSLEIPKWRDVPVPPSSDKIDTELLSDATFERRHQKYVKDEVDRKCRDARYMKEQIRLEQLRMRRNQDEVLVALDPLRASTFYPLPEDIEAIQFVNEVTVQAFGENVVNMEARDDFGVPWVDAIEAPTSIARSKALAEPVATLASKKIPTTAAEARHQENHSSYVFPKRRKRQKNRDYKDDDDK

MDKRFKWPPKKRANYLESPYPHIPSRGRQRNLHGHPNQTQHLHQHPGKIYERQQYGNGRGGHGGGNNNYRKLLHSLPAEHGGGAMAPPSSGGTVCAGADMVKLISENNNLRRMVMLNLNLMQEQTDSIAAKDKELDDQSAKMSVVKAQNEELKQAVAQLEAANQELCKQLRRKNQRRNDNDDDDDDPPLPPAAPQQKLIRCHAETQTVFREREQGTQTIDAQPQFANALPRGINMKESPALDHHAGAVTNQPASKRSESKGRGEFNGKKVSTFILQRMNQDFEHHIHEQTEVAEEHEMEAHKEQISQEEDQLVAEEDHLHMQEVHTEEVVGGDIFHDALESIEMEVVTEELVDMEEHGQSVDANGHIEEDDDEDDEDDENSDKDDDSEEDDYPWMHSDADVNARTEEELWQNQNYLLELDPTEEKTCAPSAHSTPNHQQKSSTQAEIRKEGNQNRITEKLLQLKPEPMVDALEAPILPKWVAFKKKDKEHESVPESPEVPKQQPHQEDAIVDHNAIKNQLEVPKPDLKPKDQPKDEQRQDGQLDVRVEPQEDVRKVQKETLKRQPEDAPKHLPKAVAPKVTKTSSRESTLPKANTADIKDAPAQKVIANHQSTKTQTDPVKTQRLQVKIRQYEMHPDMRTGSSAPSDIRKQKNVDPVSTPETKTIKSKSMLVNDKKTTSETSQSPDQEIDVETVRRKLAEHLKKELLSQSHSSQVTLKKIRERVATNLIYPPPSAPVSSTTITPAPTPSTTPTPGSTPQHAVTSSMDQEISAAKSKSKAAEQIATPLTPQSNSSVSSTTSTIRKTLNNCSPHTYSKATARSGKLQSRFRTATFPYSTRTWEDQEFHCDNEFFLEEADELLADNPSLEIPKWRDVPVPPSSDKIDTELLSDATFERRHQKYVKDEVDRKCRDARYMKEQIRLEQLRMRRNQDEVLVALDPLRASTFYPLPEDIEAIQFVNEVTVQAFGENVVNMEARDDFGVPWVDAIEAPTSIARSKALAEPVATLASKKIPTTAAEARHQENHSSYVFPKRRKRQKNRDYKDDDDK
Protein #8 518 residues (63% resolved)

MHHHHHHTELRDETPLFHKGEIVLCYEPDKSKARVLYTSKVLNVFERRNEHGLRFYEYKIHFQGWRPSYDRCVRATVLLKDTEENRQLQRELAEAAKLQIRGDYSYKGTPDKPSAKKKRGGKAAHVEEPIVVPMDTGHLEAEHEMAPTPRAAGNRTRDNSGGKRKEKPPSGDGRLKGNRGRQTETFYNNTINDVSVYNHVPQEDRIMMRVSERLRELIEYDRNMIKVLGKQHALPARVPIVTIMENFVKQQAVELAISIKQDSSRARNTQSRNARMEREYDRVMSTVCMLKEVVDGLRIYFEFHVDDHLLYTEEKEYVHNYLTDDNMRNCSLILNKSYEYINPSGDTELIGLDGTPVGEGSGDTNGQIGVINIGGPEYEKQLQKCLLYIVTASGKNTAQAYERTSPYTAAYKLPVEMRGFLNETFKWRLLSAESPPEKSMVFGAPHLVRLMIKMPMFLNASPISNKKLEDLLPHLDAFINYLENHREWFDRENFVNSTALPQEDLQRELLDSLDGIAA

MHHHHHHTELRDETPLFHKGEIVLCYEPDKSKARVLYTSKVLNVFERRNEHGLRFYEYKIHFQGWRPSYDRCVRATVLLKDTEENRQLQRELAEAAKLQIRGDYSYKGTPDKPSAKKKRGGKAAHVEEPIVVPMDTGHLEAEHEMAPTPRAAGNRTRDNSGGKRKEKPPSGDGRLKGNRGRQTETFYNNTINDVSVYNHVPQEDRIMMRVSERLRELIEYDRNMIKVLGKQHALPARVPIVTIMENFVKQQAVELAISIKQDSSRARNTQSRNARMEREYDRVMSTVCMLKEVVDGLRIYFEFHVDDHLLYTEEKEYVHNYLTDDNMRNCSLILNKSYEYINPSGDTELIGLDGTPVGEGSGDTNGQIGVINIGGPEYEKQLQKCLLYIVTASGKNTAQAYERTSPYTAAYKLPVEMRGFLNETFKWRLLSAESPPEKSMVFGAPHLVRLMIKMPMFLNASPISNKKLEDLLPHLDAFINYLENHREWFDRENFVNSTALPQEDLQRELLDSLDGIAA
Protein #9 827 residues (44% resolved)

MSEAELEQTPSAGHVQEQPIEEEHEPEQEPTDAYTIGGPPRTPVEDAAAELSASLDVSGSDQSAEQSLDLSGVQAEAAAESEPPAKRQHRDISPISEDSTPASSTSTSSTRSSSSSRYDDVSEAEEAPPEPEPEQPQQQQQEEKKEDGQDQVKSPGPVELEAQEPAQPQKQKEVVDQEIETEDEPSSDTVICVADINPYGSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAAPPPPPPPPAAEQVPETPASPTDDGEEPPAVYLSPYIRSRYMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDDALTMEHDNTSRETVITTGDPLMQKIDISENPDKIYFIRREDGTVHRGQVLQSRTTENAAAPDEYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVLPAPPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDH(ALY)VLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSPQTAAAVVRAPGNSG

MSEAELEQTPSAGHVQEQPIEEEHEPEQEPTDAYTIGGPPRTPVEDAAAELSASLDVSGSDQSAEQSLDLSGVQAEAAAESEPPAKRQHRDISPISEDSTPASSTSTSSTRSSSSSRYDDVSEAEEAPPEPEPEQPQQQQQEEKKEDGQDQVKSPGPVELEAQEPAQPQKQKEVVDQEIETEDEPSSDTVICVADINPYGSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAAPPPPPPPPAAEQVPETPASPTDDGEEPPAVYLSPYIRSRYMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDDALTMEHDNTSRETVITTGDPLMQKIDISENPDKIYFIRREDGTVHRGQVLQSRTTENAAAPDEYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVLPAPPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSPQTAAAVVRAPGNSG
Non polymer #10 COA

InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16+,20-/m1/s1

CC(C)(CO[P@](=O)(O)O[P@@](=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCS)O
Non polymer #11 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference