2026-10-10_00000073|medium|30GR

DOTAM-TCB: Universal Small Molecule-Guided Hapten- and T Cell Bispecfic Antibodies for Cancer Immunotherapy; X-ray diffraction 1.45Å
Protein #1 224 residues (100% resolved)

VTLKESGPVLVKPTETLTLTCTVSGFSLSTYSMSWIRQPPGKALEWLGFIGSRGDTYYASWAKGRLTISKDTSKSQVVLTMTNMDPVDTATYYCARERDPYGGGAYPPHLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC

VTLKESGPVLVKPTETLTLTCTVSGFSLSTYSMSWIRQPPGKALEWLGFIGSRGDTYYASWAKGRLTISKDTSKSQVVLTMTNMDPVDTATYYCARERDPYGGGAYPPHLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
Protein #2 218 residues (100% resolved)

IQMTQSPSSLSASVGDRVTITCQSSHSVYSDNDLAWYQQKPGKAPKLLIYQASKLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLGGYDDESDTYGFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

IQMTQSPSSLSASVGDRVTITCQSSHSVYSDNDLAWYQQKPGKAPKLLIYQASKLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLGGYDDESDTYGFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Non polymer #3 A1J6R

InChI=1S/C34H56N14O7S3/c35-27(49)20-45-12-13-46(21-28(36)50)16-17-48(23-30(38)52)26(19-47(15-14-45)22-29(37)51)18-24-7-9-25(10-8-24)41-32(56)40-11-5-3-1-2-4-6-31(53)42-33-43-44-34(57-33)58(39,54)55/h7-10,26H,1-6,11-23H2,(H2,35,49)(H2,36,50)(H2,37,51)(H2,38,52)(H2,39,54,55)(H2,40,41,56)(H,42,43,53)/t26-/m0/s1

c1cc(ccc1C[C@H]2CN(CCN(CCN(CCN2CC(=O)N)CC(=O)N)CC(=O)N)CC(=O)N)NC(=S)NCCCCCCCC(=O)Nc3nnc(s3)S(=O)(=O)N
Non polymer #4 CA

InChI=1S/Ca/q+2

[Ca+2]
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Reference