2026-10-03_00000297|hard|9ZAK

Cryo-EM structure of Leishmania tarentolae respiratory complex IV (cytochrome c oxidase dimer); Electron microscopy 3.21Å
Protein #1 223 residues (100% resolved)

MSRCTTKISGGMARANLVDHGVYVKPMSLNPFLGAVHDGTSTGYCQGYSAKPMHWLYRFRYNLLPQGISGGFFSRNPYGRYVHWLEVSTIEKLRVQLLSLEAMPVSVLTTIVIIYTLWFSYRLAFLHPDITLYNLGLWSTKPWVQQQRFNKKIDIDQQVYRWVHRVPEFAITDPIREMYRLEISANEPYLEHVRDLGREKELTLYANERTGGAGNIRPLNIPH

MSRCTTKISGGMARANLVDHGVYVKPMSLNPFLGAVHDGTSTGYCQGYSAKPMHWLYRFRYNLLPQGISGGFFSRNPYGRYVHWLEVSTIEKLRVQLLSLEAMPVSVLTTIVIIYTLWFSYRLAFLHPDITLYNLGLWSTKPWVQQQRFNKKIDIDQQVYRWVHRVPEFAITDPIREMYRLEISANEPYLEHVRDLGREKELTLYANERTGGAGNIRPLNIPH
Protein #2 179 residues (100% resolved)

FFGKGWDNAALDTIFSSMLRKPEVNDRIRTQYASTMDPRDADVLRRLGEVSKENKTFIRVFLPPHLGDPHRLLKCYSLMAYPILDDKGGQLKVEMDGCKLDAFADPDDDYSKVVIPHIELVEYLAKSLLETMKWEATPRGAASLLESLYRGAEIPDHVFQTPAVIERLEDYKDGNKVIS

FFGKGWDNAALDTIFSSMLRKPEVNDRIRTQYASTMDPRDADVLRRLGEVSKENKTFIRVFLPPHLGDPHRLLKCYSLMAYPILDDKGGQLKVEMDGCKLDAFADPDDDYSKVVIPHIELVEYLAKSLLETMKWEATPRGAASLLESLYRGAEIPDHVFQTPAVIERLEDYKDGNKVIS
Protein #3 210 residues (100% resolved)

MAFILSFWMIFLLDSVIVLLSFVCFVCVWICALLFSTVLLVSKLNNIYCTWDFTASKFIDVYWFTIGGMFSLGLLLRLCLLLYFGHLNFVSFDLCKVVGFQWYWVYFIFGETTIFSNLILESDYMIGDLRLLQCNHVLTLLSLVIYKLWLSAVDVIHSFAISSLGVKVDCIPGRCNEIVLFSSNNATVYGQCSELCGVLHGFMPIVICFI

MAFILSFWMIFLLDSVIVLLSFVCFVCVWICALLFSTVLLVSKLNNIYCTWDFTASKFIDVYWFTIGGMFSLGLLLRLCLLLYFGHLNFVSFDLCKVVGFQWYWVYFIFGETTIFSNLILESDYMIGDLRLLQCNHVLTLLSLVIYKLWLSAVDVIHSFAISSLGVKVDCIPGRCNEIVLFSSNNATVYGQCSELCGVLHGFMPIVICFI
Protein #4 157 residues (100% resolved)

MPHEDHRKYKVQREELPRMPHFNDFNDPRFCGTTNKQKNGILAYYQWLHCIGNWGEEHSMCKKMRWYVERMMHETWLEKWEEKRALGHFDHTILYGVKPWKEFEPLYQPVKKNRKGAYEYWLDRDFEPLYDADAADWREKAPILHDMFVLGKKPVAE

MPHEDHRKYKVQREELPRMPHFNDFNDPRFCGTTNKQKNGILAYYQWLHCIGNWGEEHSMCKKMRWYVERMMHETWLEKWEEKRALGHFDHTILYGVKPWKEFEPLYQPVKKNRKGAYEYWLDRDFEPLYDADAADWREKAPILHDMFVLGKKPVAE
Protein #5 200 residues (100% resolved)

MTMNFGNMTLGGAMATFGGQSNPMCNYTSPLAKKFVYKEVGKVHYPLRRHVFRTKVRTAAEIRFNEIVKRYMKEKMTFKRGCYAATITNTVELDHMGSIIPKDEYEVKRLTSYMTSKKMSSDYKKHMQELWTRVLFVCESTNLVGVTENAMHQNSRPGTDEEFMSIIWYSSFVTTLMAFVVTLFIWWYRYGQAPQYAEFK

MTMNFGNMTLGGAMATFGGQSNPMCNYTSPLAKKFVYKEVGKVHYPLRRHVFRTKVRTAAEIRFNEIVKRYMKEKMTFKRGCYAATITNTVELDHMGSIIPKDEYEVKRLTSYMTSKKMSSDYKKHMQELWTRVLFVCESTNLVGVTENAMHQNSRPGTDEEFMSIIWYSSFVTTLMAFVVTLFIWWYRYGQAPQYAEFK
Protein #6 127 residues (100% resolved)

MHSSDRFKAAWDEIPLHMLGASHKQMFEWYWRAMYQLGLRDPYRLTKLRSMLNWAALFSFMYLTYISIFYSSFYHVYMMDWPEHFKRENAREYALSHGHDVWAGDGKFIRPYFHINPPMLTMTSEDI

MHSSDRFKAAWDEIPLHMLGASHKQMFEWYWRAMYQLGLRDPYRLTKLRSMLNWAALFSFMYLTYISIFYSSFYHVYMMDWPEHFKRENAREYALSHGHDVWAGDGKFIRPYFHINPPMLTMTSEDI
Protein #7 107 residues (100% resolved)

MASCRTGRLPMPDDPLFNSTHMHGLRHSSRIAGLGMIAVIWIMYEKLRHSHHYITYKGPENPFARIRHRRFPGGAFMFGWGNNGLNRDCGIKEFECWAGYTGKEYTY

MASCRTGRLPMPDDPLFNSTHMHGLRHSSRIAGLGMIAVIWIMYEKLRHSHHYITYKGPENPFARIRHRRFPGGAFMFGWGNNGLNRDCGIKEFECWAGYTGKEYTY
Protein #8 165 residues (100% resolved)

MPRPFGVWAPATTLAEYRARIPNPFAYSFKWVYSMKREVFYPPEALAHFKDPQQFKDAVDTVIAMRVSDKIFGEGQKLPRHPVILMLMVLATHGFIIFSGLKYYYGTYMPANNPTWRKTVNKEWEEAINNSPWDHMSHVWQYSDEYAAALGDTAAPGQRKFYIPA

MPRPFGVWAPATTLAEYRARIPNPFAYSFKWVYSMKREVFYPPEALAHFKDPQQFKDAVDTVIAMRVSDKIFGEGQKLPRHPVILMLMVLATHGFIIFSGLKYYYGTYMPANNPTWRKTVNKEWEEAINNSPWDHMSHVWQYSDEYAAALGDTAAPGQRKFYIPA
Protein #9 202 residues (100% resolved)

GPTPYQDKSYPVQPHNLDELQQPPDSWRKSPIMSKLMDQSLPVYDDVVTGVGRLYWQEPARVWHLFEADDTLMLEEHDREEWNDRPYVAVNHLYEPPIGSEERPIRVEGTGNPGDQQIVLCFGNCAPHVPQSNYYMMMKGYNKTKCPMCQQWFYIHNRPWLVMHPDWTDEPAADEGPAYTFSEIEAEFDRDFHEFGVYLNAE

GPTPYQDKSYPVQPHNLDELQQPPDSWRKSPIMSKLMDQSLPVYDDVVTGVGRLYWQEPARVWHLFEADDTLMLEEHDREEWNDRPYVAVNHLYEPPIGSEERPIRVEGTGNPGDQQIVLCFGNCAPHVPQSNYYMMMKGYNKTKCPMCQQWFYIHNRPWLVMHPDWTDEPAADEGPAYTFSEIEAEFDRDFHEFGVYLNAE
Protein #10 95 residues (100% resolved)

HFPLSPPPIEIDYLDSDPLEFAVRTEARRWGFDDLQYMRELAFVRIKENPSIGDFRRMTPEERRDLFWGSDRQDFFRYITLKLTGHPEHLYHRGW

HFPLSPPPIEIDYLDSDPLEFAVRTEARRWGFDDLQYMRELAFVRIKENPSIGDFRRMTPEERRDLFWGSDRQDFFRYITLKLTGHPEHLYHRGW
Protein #11 110 residues (100% resolved)

YMLAFNSKAKARPNFGLRGVGYWTSEVYHKPGQNYWMVVCCAGPFLLVGAIMMDGFWSKLDDIAGGGPSALDYGWRSQDRKPWDFSFDIGEGYAAGPAVYRPASGAVDLG

YMLAFNSKAKARPNFGLRGVGYWTSEVYHKPGQNYWMVVCCAGPFLLVGAIMMDGFWSKLDDIAGGGPSALDYGWRSQDRKPWDFSFDIGEGYAAGPAVYRPASGAVDLG
Protein #12 549 residues (100% resolved)

MFWLCLVCLSVSHKMIGLCYLLVAILSGFVGYVYSLFIRLELSLIGCGILFGDYQFYNVLITSHGLIMVFAFIMPVMMGGLVNYFIPVMAGFPDMVFPRLNNMSFWMYLAGFGCVVNGFLTEEGMGVGWTLYPTLICIDFHSSLACDFVMFAVHLLGISSILNSINLLGTLFCCRRKFFSFLSWSLFIWAALITAILLIITLPVLAGGVTLILCDRNFNTSFYDVVGGGDLILFQHIFWFFGHPEVYIILLPVFGLISTIVEVIGFRCVFSTVAMIYSMILIAILGMFVWAHHMFVVGMDVDSRAYFGGVSILIGLPTCVKLFNWIYSFLYTDMIITFEVYFVIMFIFMFLIGAVTGLFLSNVGIDIMLHDTYFVVGHFHYVLSLGAVVGFFTGFIHFLAKWLPIELYLFWMFYFISTLFIGSNMLFFPMHSLGMYAFPRRISDYPVSFLFWSSFMLYGMLLLASLILFLCALFCVFLFWDYCLFFVSLFVFSLYCFFYFSTWLPCVMVLYLLLVDFAHIVLDYLFLILCFCFVFFIFFWQSLFLFFYI

MFWLCLVCLSVSHKMIGLCYLLVAILSGFVGYVYSLFIRLELSLIGCGILFGDYQFYNVLITSHGLIMVFAFIMPVMMGGLVNYFIPVMAGFPDMVFPRLNNMSFWMYLAGFGCVVNGFLTEEGMGVGWTLYPTLICIDFHSSLACDFVMFAVHLLGISSILNSINLLGTLFCCRRKFFSFLSWSLFIWAALITAILLIITLPVLAGGVTLILCDRNFNTSFYDVVGGGDLILFQHIFWFFGHPEVYIILLPVFGLISTIVEVIGFRCVFSTVAMIYSMILIAILGMFVWAHHMFVVGMDVDSRAYFGGVSILIGLPTCVKLFNWIYSFLYTDMIITFEVYFVIMFIFMFLIGAVTGLFLSNVGIDIMLHDTYFVVGHFHYVLSLGAVVGFFTGFIHFLAKWLPIELYLFWMFYFISTLFIGSNMLFFPMHSLGMYAFPRRISDYPVSFLFWSSFMLYGMLLLASLILFLCALFCVFLFWDYCLFFVSLFVFSLYCFFYFSTWLPCVMVLYLLLVDFAHIVLDYLFLILCFCFVFFIFFWQSLFLFFYI
Protein #13 287 residues (100% resolved)

MFVRVIFVGVSGVFVFLSLPAICIVYLTFCLCGLFCIMFGSFIFIDYCFICFFACLLFCLVCLLCDLFVDSLRGLFDVCCFIRCIQYCFVWFIISELLLFLSLFYVVFSLVLFVSVEFAFVFVIPVMFSCLICDFGFVFYWYFIDIFNLLINTFLLFVSGLFVNFVLFLFWFRFFLCVLFMLWVGILFGFLFLWNQVWEFALLFVTCSCGVFGSILFLIDLLHFSHVFLGIFLLFLCFSRCFNFLCMDTRFVFLYVVCLYWHFVDCVWFFLLRFVYFDVLSVVYLYA

MFVRVIFVGVSGVFVFLSLPAICIVYLTFCLCGLFCIMFGSFIFIDYCFICFFACLLFCLVCLLCDLFVDSLRGLFDVCCFIRCIQYCFVWFIISELLLFLSLFYVVFSLVLFVSVEFAFVFVIPVMFSCLICDFGFVFYWYFIDIFNLLINTFLLFVSGLFVNFVLFLFWFRFFLCVLFMLWVGILFGFLFLWNQVWEFALLFVTCSCGVFGSILFLIDLLHFSHVFLGIFLLFLCFSRCFNFLCMDTRFVFLYVVCLYWHFVDCVWFFLLRFVYFDVLSVVYLYA
Protein #14 93 residues (100% resolved)

FYANCGETGISGATMQVLLKLTLACCVVQVFAIRYFVFQRLTTKKQFVEDSTDLWESDGTEMDGEEAVANLRIQHERIMPFMNDIKDKLDAQA

FYANCGETGISGATMQVLLKLTLACCVVQVFAIRYFVFQRLTTKKQFVEDSTDLWESDGTEMDGEEAVANLRIQHERIMPFMNDIKDKLDAQA
Protein #15 82 residues (100% resolved)

SYTELSHMKFPVYYGAVGVVLGYFVVMWVVFLRMGSKHTARSEFKNDYLRVWRRRLGTGYEWADAWGPEMGTFFKDLPEEVE

SYTELSHMKFPVYYGAVGVVLGYFVVMWVVFLRMGSKHTARSEFKNDYLRVWRRRLGTGYEWADAWGPEMGTFFKDLPEEVE
Protein #16 311 residues (100% resolved)

HDRWYGHALELDTHNYKFNGEPPSWMKTHAKTEEETSFAKSVLPHIDFASSYECLLFDADRLNTNLNRKEFGNEIKYRLEKQANTVARAQQLLKDKKAGTGPDAAKIENTLIARIFDEEHVQAEMKYVKCIRANELAEDNRLDILPGGSPNSLREKTRWNLNTELHPADRAEIGARLTAWLPEKYHIVYFDDFQTVAANDATARREMLEIVESVQKEYTAEAKEGGYESDLKETVAELMDDVDPTRAITMEAIKSCKDLQQLEDWSRQVHEYNGDDRIIEIYARAAEITKNAEHQALVKQMREWRKLATKN

HDRWYGHALELDTHNYKFNGEPPSWMKTHAKTEEETSFAKSVLPHIDFASSYECLLFDADRLNTNLNRKEFGNEIKYRLEKQANTVARAQQLLKDKKAGTGPDAAKIENTLIARIFDEEHVQAEMKYVKCIRANELAEDNRLDILPGGSPNSLREKTRWNLNTELHPADRAEIGARLTAWLPEKYHIVYFDDFQTVAANDATARREMLEIVESVQKEYTAEAKEGGYESDLKETVAELMDDVDPTRAITMEAIKSCKDLQQLEDWSRQVHEYNGDDRIIEIYARAAEITKNAEHQALVKQMREWRKLATKN
Protein #17 128 residues (100% resolved)

TVAKISSIERASTYLRFSTLRVHPHHEPNFRARPVGWKAWNSKQYMDPWAPYPLTSPVRHVDRPFSGMWFGMGHFALKNFFGPLNWKFWARVSFFGTLGWAYSLSSYALRMHRNGWEWKNRGAVFSMD

TVAKISSIERASTYLRFSTLRVHPHHEPNFRARPVGWKAWNSKQYMDPWAPYPLTSPVRHVDRPFSGMWFGMGHFALKNFFGPLNWKFWARVSFFGTLGWAYSLSSYALRMHRNGWEWKNRGAVFSMD
Non polymer #18 CU

InChI=1S/Cu/q+2

[Cu+2]
Non polymer #19 HEA

InChI=1S/C49H58N4O6.Fe/c1-9-34-31(6)39-25-45-49(46(55)18-12-17-30(5)16-11-15-29(4)14-10-13-28(2)3)33(8)40(52-45)24-44-37(27-54)36(20-22-48(58)59)43(53-44)26-42-35(19-21-47(56)57)32(7)38(51-42)23-41(34)50-39;/h9,13,15,17,23-27,46,55H,1,10-12,14,16,18-22H2,2-8H3,(H4,50,51,52,53,54,56,57,58,59);/q;+2/p-2/b29-15+,30-17+,38-23-,39-25-,40-24-,41-23-,42-26-,43-26-,44-24-,45-25-;/t46-;/m0./s1

Cc1c2n3c(c1C=C)C=C4C(=C(C5=[N]4[Fe]36[N]7=C(C=C8N6C(=C5)C(=C8C=O)CCC(=O)O)C(=C(C7=C2)[C@H](CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)O)C)CCC(=O)O)C
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Reference