2026-10-03_00000282|ligand|9YHP

FEM1B with small molecule activator; X-ray diffraction 3.50Å
Protein #1 379 residues (99% resolved)

AAMEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIMKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELEAIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKG

AAMEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIMKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELEAIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKG
Protein #2 31 residues (48% resolved)

GRNKSSLLFKESEETRTPNCNCKYCSHPVLG

GRNKSSLLFKESEETRTPNCNCKYCSHPVLG
Protein #3 66 residues (100% resolved)

DAEAVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLP

DAEAVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLP
Non polymer #4 A1CW4

InChI=1S/C20H20BrN3O4S/c1-11-5-8-17(16(21)9-11)24-29(26,27)18-10-15(7-6-12(18)2)19-13(3)23-28-20(19)22-14(4)25/h5-10,24H,1-4H3,(H,22,25)

Cc1ccc(c(c1)Br)NS(=O)(=O)c2cc(ccc2C)c3c(noc3NC(=O)C)C
Non polymer #5 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference