2026-10-03_00000161|hard|45AR

Crystal structure of C11 nanobody in complex with human MR1-5-OP-RU; X-ray diffraction 3.00Å

Protein #1 271 residues (96% resolved)

Raw Sequence ...

MRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHSGVHMVLQVP

Canonical Sequence ...

Protein #2 100 residues (99% resolved)

Raw Sequence ...

MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Canonical Sequence ...

MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Protein #3 128 residues (95% resolved)

Raw Sequence ...

QVQLVESGGGLVQAGGSLRLSCAASGGIIVQYVMRWYRQAPGKEREFVAAISLRGGDTYYADSVKGRFTISRDNAKNIVYLQMNSLKPEDTAVYYCAADSGYYLDDYDYWGQGTQVTVSSLEHHHHHH

Canonical Sequence ...

QVQLVESGGGLVQAGGSLRLSCAASGGIIVQYVMRWYRQAPGKEREFVAAISLRGGDTYYADSVKGRFTISRDNAKNIVYLQMNSLKPEDTAVYYCAADSGYYLDDYDYWGQGTQVTVSSLEHHHHHH

Non polymer #4 2LJ

InChI=1S/C12H20N4O6/c1-2-3-13-8-10(15-12(22)16-11(8)21)14-4-6(18)9(20)7(19)5-17/h3,6-7,9,17-20H,2,4-5H2,1H3,(H3,14,15,16,21,22)/b13-3+/t6-,7+,9-/m0/s1

SMILES: CC/C=N/C1=C(NC(=O)NC1=O)NC[C@@H]([C@@H]([C@@H](CO)O)O)O

CC/C=N/C1=C(NC(=O)NC1=O)NC[C@@H]([C@@H]([C@@H](CO)O)O)O

Non polymer #5 NA

InChI=1S/Na/q+1

SMILES: [Na+]

[Na+]

Biounit #1 hetero-1-1-1-mer

Reference