2026-10-03_00000127|ligand|37DN

Discovery of CNS Penetrant Transthyretin (TTR) Stabilizers with Heterocyclic Linkers; X-ray diffraction 1.65Å
Protein #1 127 residues (91% resolved)

GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
Non polymer #2 A1DM0

InChI=1S/C16H22N4O/c1-11-15(12(2)19-18-11)20-9-6-13(7-10-20)14-5-4-8-17-16(14)21-3/h4-5,8,13H,6-7,9-10H2,1-3H3,(H,18,19)

Cc1c(c(n[nH]1)C)N2CCC(CC2)c3cccnc3OC
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Reference