2026-10-03_00000126|ligand|37DK

Discovery of CNS Penetrant Transthyretin (TTR) Stabilizers with Heterocyclic Linkers; X-ray diffraction 1.16Å
Protein #1 127 residues (91% resolved)

GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
Non polymer #2 A1DMZ

InChI=1S/C16H21N3/c1-12-16(13(2)18-17-12)19-10-8-15(9-11-19)14-6-4-3-5-7-14/h3-7,15H,8-11H2,1-2H3,(H,17,18)

Cc1c(c(n[nH]1)C)N2CCC(CC2)c3ccccc3
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Reference