2026-09-26_00000071
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ligand
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26FF
Crystal structure of the second bromodomain (BD2) of human Bromodomain-containing protein 4 (BRD4) complexed with 2-(benzylamino)pyrimidin-4(3H)-one;
X-ray diffraction 2.40Å
Protein #1
130 residues (84% resolved)
Raw Sequence ...
SMKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
Canonical Sequence ...
SMKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
Non polymer #2
A1MGQ
InChI=1S/C11H11N3O/c15-10-6-7-12-11(14-10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,12,13,14,15)
InChI=1S/C11H11N3O/c15-10-6-7-12-11(14-10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,12,13,14,15)
SMILES: c1ccc(cc1)CNC2=NC=CC(=O)N2
c1ccc(cc1)CNC2=NC=CC(=O)N2
Biounit #1
homo-dimer
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Model
Reference
100%