2026-09-12_00000103|ligand|35UC

Crystal structure of 2-amino-[1,2,4]triazolo[1,5-a]pyridine derivative bound to KIT; X-ray diffraction 2.33Å
Protein #1 339 residues (93% resolved)

GPMDPTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHI

GPMDPTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHI
Non polymer #2 A1DMF

InChI=1S/C18H16FN7O/c1-11-2-3-15(14(19)6-11)22-17(27)10-25-9-13(8-21-25)12-4-5-26-16(7-12)23-18(20)24-26/h2-9H,10H2,1H3,(H2,20,24)(H,22,27)

Cc1ccc(c(c1)F)NC(=O)Cn2cc(cn2)c3ccn4c(c3)nc(n4)N
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Reference