2026-09-12_00000040|ligand|22WR

local refinement of 5HT2AR-miniGq heterotrimer in complex with a selective agonist IHCH-2330; Electron microscopy 3.20Å
Protein #1 336 residues (76% resolved)

GPGSGSGLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY

GPGSGSGLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY
Non polymer #2 A1EXY

InChI=1S/C23H26F3N3O3/c1-15-17(22(30)29-10-6-5-7-21(29)27-15)9-12-28(2)11-8-16-13-20(32-4)18(23(24,25)26)14-19(16)31-3/h5-7,10,13-14H,8-9,11-12H2,1-4H3

CC1=C(C(=O)N2C=CC=CC2=N1)CCN(C)CCc3cc(c(cc3OC)C(F)(F)F)OC
Download coordinates
Reference