2026-09-12_00000015|ligand|13AH

Crystal structure of retinol-binding protein 4 in complex with tinlarebant; X-ray diffraction 2.10Å

Protein #1 184 residues (97% resolved)

Raw Sequence ...

MERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL

Canonical Sequence ...

MERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL

Non polymer #2 A1DE1

InChI=1S/C21H21F5N4O2/c1-11(31)30-9-6-14-16(10-30)27-28-19(14)20(32)29-7-4-12(5-8-29)13-2-3-15(22)18(23)17(13)21(24,25)26/h2-3,12H,4-10H2,1H3,(H,27,28)

SMILES: CC(=O)N1CCc2c([nH]nc2C(=O)N3CCC(CC3)c4ccc(c(c4C(F)(F)F)F)F)C1

CC(=O)N1CCc2c([nH]nc2C(=O)N3CCC(CC3)c4ccc(c(c4C(F)(F)F)F)F)C1

Non polymer #3 NA

InChI=1S/Na/q+1

SMILES: [Na+]

[Na+]

Reference