2026-08-29_00000279|medium|9ZW6

Structure of the HMG-CoA reductase from Borrelia burgdorferi bound to HMG-CoA; X-ray diffraction 2.55Å
Protein #1 437 residues (94% resolved)

HHHHHHMNLESLSSFMELSKNFRHKSVLEKRQEIKSFLELSYKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKNLKINGKYYSLPIATEESSVVAALNFAAKILENADLRYSLGEVLGISQIYIKSEKDLSKIFVDLGDKIKTWIEPLLTNMNQRGGGFRRLSTRHIKELGIQKLNIYVDTCDAMGANLLNSIAERVAEFIFLEFGYECVLKVLSNDISEFTAKARFVLDFKHLLPGKEDSWNLAKKIELISSIGFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASVHKFASKSGKYFPLSKFYTTDNALVGEIEIPLQVGTKGGVISFNEASILSFKIMNVNSKSEFIGILSCVGLASNFAALRALAFNGIQKGHMRLHVNKILHLLKTKYNISDFEKDKLLLEMERMNIYSFDFAFKILKKIRLENENKV

HHHHHHMNLESLSSFMELSKNFRHKSVLEKRQEIKSFLELSYKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKNLKINGKYYSLPIATEESSVVAALNFAAKILENADLRYSLGEVLGISQIYIKSEKDLSKIFVDLGDKIKTWIEPLLTNMNQRGGGFRRLSTRHIKELGIQKLNIYVDTCDAMGANLLNSIAERVAEFIFLEFGYECVLKVLSNDISEFTAKARFVLDFKHLLPGKEDSWNLAKKIELISSIGFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASVHKFASKSGKYFPLSKFYTTDNALVGEIEIPLQVGTKGGVISFNEASILSFKIMNVNSKSEFIGILSCVGLASNFAALRALAFNGIQKGHMRLHVNKILHLLKTKYNISDFEKDKLLLEMERMNIYSFDFAFKILKKIRLENENKV
Non polymer #2 HMG

InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/p-5/t14-,19-,20-,21+,25-,27+/m1/s1

C[C@](CC(=O)[O-])(CC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)OP(=O)([O-])[O-])O)O
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Reference