2026-08-29_00000054|hard|23VW

Cryo-EM structure of the TfCas12m3-crRNA-tgDNA ternary complex; Electron microscopy 2.39Å
Protein #1 577 residues (94% resolved)

MGHHHHHHGGMETAATKNYLALSFGCLSPTRGEEYLLDQIKKKHDLWNKLVEKDREHREKVRQVMVFESETTKKIKELEEELNSLREEIKNQRKTKRTGKVDLTDQKARIEEIKPQLKQLKEKFKEERSFIFEARKQELAQLEKERWAVVKELGKGSGLYWCNLEDVVNSYDIGRKKAKAAGGEMRFHRWDGTGKVTVRFQKGLPVNEMFSCTNNLLQIDPVDKDAWYNPVRAIRRKKSRTRVRLRACSENKKPLFIELPVVLHREIPEDALIRTASVIREKVGMRYRYKLNLVLEILGENTNRILPALEGTAAIDLGWRTVKDGLRVACLVDDKGHSEELILDNDVLHEFNKIKDLQSIRDNLFNETKAKLMELLKTLELPDEAKERTSHMANWRSQQKMLRLHQYWRENRLPGDDEVWEVLEYWRKREIHLYEWQENLRDQVLRRRKEIYRIFAAKITRKYKTIVLEEFTLNKTVQKPNPEEGPAGTLPANRNRFIAAISEFRNELANACRKNHVEFTYVPAENTTITCHKCGHKEKFDAAAQIIHTCSTCGELWDQDYNAAKNLLAFSQKGGVK

MGHHHHHHGGMETAATKNYLALSFGCLSPTRGEEYLLDQIKKKHDLWNKLVEKDREHREKVRQVMVFESETTKKIKELEEELNSLREEIKNQRKTKRTGKVDLTDQKARIEEIKPQLKQLKEKFKEERSFIFEARKQELAQLEKERWAVVKELGKGSGLYWCNLEDVVNSYDIGRKKAKAAGGEMRFHRWDGTGKVTVRFQKGLPVNEMFSCTNNLLQIDPVDKDAWYNPVRAIRRKKSRTRVRLRACSENKKPLFIELPVVLHREIPEDALIRTASVIREKVGMRYRYKLNLVLEILGENTNRILPALEGTAAIDLGWRTVKDGLRVACLVDDKGHSEELILDNDVLHEFNKIKDLQSIRDNLFNETKAKLMELLKTLELPDEAKERTSHMANWRSQQKMLRLHQYWRENRLPGDDEVWEVLEYWRKREIHLYEWQENLRDQVLRRRKEIYRIFAAKITRKYKTIVLEEFTLNKTVQKPNPEEGPAGTLPANRNRFIAAISEFRNELANACRKNHVEFTYVPAENTTITCHKCGHKEKFDAAAQIIHTCSTCGELWDQDYNAAKNLLAFSQKGGVK
DNA #2 39 bases

(DG)(DC)(DA)(DC)(DT)(DT)(DG)(DC)(DC)(DG)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DA)(DC)(DG)(DT)(DA)(DT)(DG)(DC)(DG)

GCACTTGCCGTTTTTTTTTTTTTTTTTTTTACGTATGCG
DNA #3 39 bases

(DC)(DG)(DC)(DA)(DT)(DA)(DC)(DG)(DT)(DG)(DT)(DG)(DA)(DA)(DG)(DC)(DG)(DC)(DA)(DG)(DC)(DT)(DA)(DA)(DT)(DT)(DT)(DA)(DC)(DC)(DG)(DG)(DC)(DA)(DA)(DG)(DT)(DG)(DC)

CGCATACGTGTGAAGCGCAGCTAATTTACCGGCAAGTGC
RNA #4 59 bases

GGGUUGCAAUGCCUAGCUCAGAGGUUUAAAGACUGAGACGUAAAUUAGCUGCGCUUCAC

GGGUUGCAAUGCCUAGCUCAGAGGUUUAAAGACUGAGACGUAAAUUAGCUGCGCUUCAC
Non polymer #5 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #6 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference