2026-08-22_00000473|hard|9WPE

Cryo-EM structure of the insect sex pheromone receptor ApisOR22-Orco heterocomplex bound with nepetalactone in the closed state.; Electron microscopy 3.10Å
Protein #1 445 residues (75% resolved)

MKDILLNSIMHRNDSWIGSKIASSAALTNDGGGDEMTIHQDNSSNERDYQCEDGGTAMDVKLFKAIGMYQLLHPVECGLNSDLCRKTAMMVVGLTVGLQLMQVFRLYLARHDIPMFANMAMLVVYGFMCLLKGYTLANHADRICITLEVARYAFTDCGRRDPSLMRRCRARLSTILRTFVGLSFGTLVVWLVMPWFLASEYDGKPLIWAVVYVVESIILTVNVFCWTSFDCYLVTMCFVFEAMFRTMSSGYEKVGRGQPIHPHTNQPFGDHRRSDSEVKANVTLTFPSHYDDLISHIKDNQKIVEKYKTFFEIVTPTVLLQIADGSYTIITMIFLISIAYLNGNSILSPMILKYVCGLVSLTIELYIFCYAFNYIEDGRSTVNFGLYSCDWTDKDLKFKKTVLLAMSMNSANKQVMKLSPNSIVNLEMFSRVMNMSYTIVSTLLS

MKDILLNSIMHRNDSWIGSKIASSAALTNDGGGDEMTIHQDNSSNERDYQCEDGGTAMDVKLFKAIGMYQLLHPVECGLNSDLCRKTAMMVVGLTVGLQLMQVFRLYLARHDIPMFANMAMLVVYGFMCLLKGYTLANHADRICITLEVARYAFTDCGRRDPSLMRRCRARLSTILRTFVGLSFGTLVVWLVMPWFLASEYDGKPLIWAVVYVVESIILTVNVFCWTSFDCYLVTMCFVFEAMFRTMSSGYEKVGRGQPIHPHTNQPFGDHRRSDSEVKANVTLTFPSHYDDLISHIKDNQKIVEKYKTFFEIVTPTVLLQIADGSYTIITMIFLISIAYLNGNSILSPMILKYVCGLVSLTIELYIFCYAFNYIEDGRSTVNFGLYSCDWTDKDLKFKKTVLLAMSMNSANKQVMKLSPNSIVNLEMFSRVMNMSYTIVSTLLS
Protein #2 463 residues (87% resolved)

MGYKKDGLIKDLWPNIRLIQLSGLFISEYYDDYSGLAVLFRKIYSWITAIIIYSQFIFIVIFMVTKSNDSDQLAAGVVTTLFFTHSMIKFVYFSTGTKSFYRTLSCWNNTSPHPLFAESHSRFHAKSLSRMRQLLIIVSIVTIFTTISWTTITFFGESVWKVPDPETFNQTMYVPVPRLMLHSWYPWDSGHGLGYIVAFVLQFYWVFITLSHSNLMELLFSSFLVHACEQLQHLKEILNPLIELSATLDSSVHNPAEIFRANSAKNQSINGIDHDYNGSYVNEITEYGTKGENEPNRKGPNNLTSNQEVLVRSAIKYWVERHKHVVKYVSLITECYGSALLFHMLVSTVILTILAYQATKINGVNVFAFSTIGYLMYSFAQIFMFCIHGNELIEESSSVMEAAYGCHWYDGSEEAKTFVQIVCQQCQKPLIVSGAKFFNVSLDLFASVLGAVVTYFMVLVQLK

MGYKKDGLIKDLWPNIRLIQLSGLFISEYYDDYSGLAVLFRKIYSWITAIIIYSQFIFIVIFMVTKSNDSDQLAAGVVTTLFFTHSMIKFVYFSTGTKSFYRTLSCWNNTSPHPLFAESHSRFHAKSLSRMRQLLIIVSIVTIFTTISWTTITFFGESVWKVPDPETFNQTMYVPVPRLMLHSWYPWDSGHGLGYIVAFVLQFYWVFITLSHSNLMELLFSSFLVHACEQLQHLKEILNPLIELSATLDSSVHNPAEIFRANSAKNQSINGIDHDYNGSYVNEITEYGTKGENEPNRKGPNNLTSNQEVLVRSAIKYWVERHKHVVKYVSLITECYGSALLFHMLVSTVILTILAYQATKINGVNVFAFSTIGYLMYSFAQIFMFCIHGNELIEESSSVMEAAYGCHWYDGSEEAKTFVQIVCQQCQKPLIVSGAKFFNVSLDLFASVLGAVVTYFMVLVQLK
Non polymer #3 A1EX6

InChI=1S/C10H14O2/c1-6-3-4-8-7(2)5-12-10(11)9(6)8/h5-6,8-9H,3-4H2,1-2H3/t6-,8+,9+/m0/s1

C[C@H]1CC[C@H]2[C@@H]1C(=O)OC=C2C
Non polymer #4 PC1

InChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P@@](=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
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Reference