2026-08-22_00000427|hard|9WAF

Cryo-EM structure of helicase DruE in the Druantia anti-phage system elucidates its anti-phage mechanism; Electron microscopy 3.29Å
Protein #1 1970 residues (97% resolved)

MGSSHHHHHHSQDPMVLDPIGGFHRIQDFFISYVETSFRISNPTAAEARRALLKTCGILATEPFIEPVLRYESSDKNLEDLIEEEDGTLQPLSLEGRKAFVELALSGLFDGEPSKGLLRRKSAYAPYRHQISMLERGVRAGCPGIVTSGTGSGKTESFMLPVLAALANEAVDWPKPGVNYLQEHWWQTPKSRWSPRRAGEKRPAAVRALVLYPMNALVEDQMVRLRKTLDAEEAHAVMDERFTGNRLFFGQYTSATPVTGYEQHPRLAGDKQEVKRRARRIARLRKAMQNFQRDQDAARRFDADVQSDGKASVEKTRYIFPSVDGGEMVSRWDMHAAPPDILVTNASMLGAMLSREIEDAIFEKTREWLMSDEDAYFYLIFDELHLIRGSAGTEIALLIKSLIQRLGLDQPEHCYKLRLLASSASLPMEGVEGVQSRTYLRDLFAPFGTSSRPNDLGSIDPSFWSKCIIQGVVHIPPVQQCGIPAEPFVQLMKAALEGKDNFVGQLDRTPALDAAIVQAAKVLGITETEQTTLVKQLAETAASLLTHACKNDGTIRATTPRSIAARIFAPATGDTELALRGLLLARSLPESNQSAVKVAVATPAFRVHTFIRNIEGLFASVAPGEPDVAFDNFSVERGTSHSAPVEGQRRGHRLFELLYCEACGDLFVGGQRGQSSGSMNATELLPSAANLEHLPERPGAEYYDDMTLDEFAVFWPRRGDWIGSDKGYDQWEPAHLNPDTGIVEIGEIAKEGNIAGYLYYQTKAAVSKDKERSTQQPSAQPFCCPKCGTDYSNRPDTNRSRSPIRAFRTGVTKSSQLVATELFELLHAIGAEPKGIVFSDSRQDAAAQAMEIERLHLRDLRREVLVTAARSYVKDASIEVLTSKEIIERLIKAETAGDKDEVIRLSELLKKQTVACGPKTRKVKLDKLLEFGNDGSIGRITAELVRLGISPYKHSSSNDAKELPWYREFEKNGDLIAYDHTLSYTQTVGLNKDIVEGQYELIDDVIFANTFFALEETGLAYPCLPMDEDDQALDAWLRVFASAYRVKDNRYFDKNKVKLWQKGPDVTNGRIKKVARALYGETRYGDELTRVLGEFERLGHRGGLFNIGKLALKVTEPGDDFWRCSNCERVHLHRGLGVCTRCVAPLHEPSGKVEALWETNFLGRRIVRGERDGVGRFRLRVEELTGQTDDFSDRLRKFKGIFVDDVSELEKLASEIDMLSVTTTMEVGIDIGALQTVYQANMPPQRFNYQQRVGRAGRRGQAFSFVVTFCRGRSHDAYYFAHPQAITGDPPPPPFLATGHDAIPMRLLRKTWLRAAFKQLREQCAKLGESFPGDLLIPPDVHGEYVTTKDYYHSQEIDWPIRLSEALKQTQSVRDRFIETATFDQEQRQRLYAKSSIDLLLKEINDQRPHAPDDEVGLARFLAERGLLPMYGMPTRVRNLYVGLRESKTQSDHSEYEWSMMDRDLDLAVFEYAPGAVLVKDKKKHRVIGFTGNLTDPQAQGRSIEGIRSVTDWSESQTYVAICPACGSASQSKQAPEGPLACNDCQAPIPKESFLHYVTPAAFRTDFLPKDELDEFERMSLRTVATVLREGDCFNYRALTVRSGAGVTILQLNDGPTDGKNDGQRFTVDLVQDQRVPVPFSTQRPAIDGIQAIESSWRRSHISPRWSQPLSEQRFGLISQKETDSIHLELTRFDKRLTLDMVSRKGDFMHLPTRAAAISATQILVNKAALALDVSPDEFEALEPRLRSGHPMLQIADALINGSGLSRRLGEPASDGPTPLLVDLLHEILEKPNVWPLQDFLRTGAEGPHAAQCQTSCYRCIQRYGNRRYHGLLDWRLGLAYLRTLVTPAYACGLTPGDDKYPEIQGWRERASQLADDVEAMRKGTIRTERLPHSDLPCLIEQKDGVELWRAVVIHPLWRHSEPGVMRDLLGADWSPSLRYLDTFELERRPLRRLAALKQEGSWSHPQFEK

MGSSHHHHHHSQDPMVLDPIGGFHRIQDFFISYVETSFRISNPTAAEARRALLKTCGILATEPFIEPVLRYESSDKNLEDLIEEEDGTLQPLSLEGRKAFVELALSGLFDGEPSKGLLRRKSAYAPYRHQISMLERGVRAGCPGIVTSGTGSGKTESFMLPVLAALANEAVDWPKPGVNYLQEHWWQTPKSRWSPRRAGEKRPAAVRALVLYPMNALVEDQMVRLRKTLDAEEAHAVMDERFTGNRLFFGQYTSATPVTGYEQHPRLAGDKQEVKRRARRIARLRKAMQNFQRDQDAARRFDADVQSDGKASVEKTRYIFPSVDGGEMVSRWDMHAAPPDILVTNASMLGAMLSREIEDAIFEKTREWLMSDEDAYFYLIFDELHLIRGSAGTEIALLIKSLIQRLGLDQPEHCYKLRLLASSASLPMEGVEGVQSRTYLRDLFAPFGTSSRPNDLGSIDPSFWSKCIIQGVVHIPPVQQCGIPAEPFVQLMKAALEGKDNFVGQLDRTPALDAAIVQAAKVLGITETEQTTLVKQLAETAASLLTHACKNDGTIRATTPRSIAARIFAPATGDTELALRGLLLARSLPESNQSAVKVAVATPAFRVHTFIRNIEGLFASVAPGEPDVAFDNFSVERGTSHSAPVEGQRRGHRLFELLYCEACGDLFVGGQRGQSSGSMNATELLPSAANLEHLPERPGAEYYDDMTLDEFAVFWPRRGDWIGSDKGYDQWEPAHLNPDTGIVEIGEIAKEGNIAGYLYYQTKAAVSKDKERSTQQPSAQPFCCPKCGTDYSNRPDTNRSRSPIRAFRTGVTKSSQLVATELFELLHAIGAEPKGIVFSDSRQDAAAQAMEIERLHLRDLRREVLVTAARSYVKDASIEVLTSKEIIERLIKAETAGDKDEVIRLSELLKKQTVACGPKTRKVKLDKLLEFGNDGSIGRITAELVRLGISPYKHSSSNDAKELPWYREFEKNGDLIAYDHTLSYTQTVGLNKDIVEGQYELIDDVIFANTFFALEETGLAYPCLPMDEDDQALDAWLRVFASAYRVKDNRYFDKNKVKLWQKGPDVTNGRIKKVARALYGETRYGDELTRVLGEFERLGHRGGLFNIGKLALKVTEPGDDFWRCSNCERVHLHRGLGVCTRCVAPLHEPSGKVEALWETNFLGRRIVRGERDGVGRFRLRVEELTGQTDDFSDRLRKFKGIFVDDVSELEKLASEIDMLSVTTTMEVGIDIGALQTVYQANMPPQRFNYQQRVGRAGRRGQAFSFVVTFCRGRSHDAYYFAHPQAITGDPPPPPFLATGHDAIPMRLLRKTWLRAAFKQLREQCAKLGESFPGDLLIPPDVHGEYVTTKDYYHSQEIDWPIRLSEALKQTQSVRDRFIETATFDQEQRQRLYAKSSIDLLLKEINDQRPHAPDDEVGLARFLAERGLLPMYGMPTRVRNLYVGLRESKTQSDHSEYEWSMMDRDLDLAVFEYAPGAVLVKDKKKHRVIGFTGNLTDPQAQGRSIEGIRSVTDWSESQTYVAICPACGSASQSKQAPEGPLACNDCQAPIPKESFLHYVTPAAFRTDFLPKDELDEFERMSLRTVATVLREGDCFNYRALTVRSGAGVTILQLNDGPTDGKNDGQRFTVDLVQDQRVPVPFSTQRPAIDGIQAIESSWRRSHISPRWSQPLSEQRFGLISQKETDSIHLELTRFDKRLTLDMVSRKGDFMHLPTRAAAISATQILVNKAALALDVSPDEFEALEPRLRSGHPMLQIADALINGSGLSRRLGEPASDGPTPLLVDLLHEILEKPNVWPLQDFLRTGAEGPHAAQCQTSCYRCIQRYGNRRYHGLLDWRLGLAYLRTLVTPAYACGLTPGDDKYPEIQGWRERASQLADDVEAMRKGTIRTERLPHSDLPCLIEQKDGVELWRAVVIHPLWRHSEPGVMRDLLGADWSPSLRYLDTFELERRPLRRLAALKQEGSWSHPQFEK
DNA #2 70 bases

(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DC)(DA)(DT)(DC)(DG)(DA)(DT)(DG)(DA)(DG)(DC)(DA)(DC)(DT)(DG)(DC)(DT)(DA)(DT)(DT)(DC)(DC)(DC)(DT)(DA)(DG)(DC)(DA)(DG)(DT)(DG)(DC)(DT)(DC)(DA)(DT)(DC)(DG)(DA)(DT)(DG)(DA)(DT)(DT)(DT)(DT)(DC)(DA)(DT)(DC)(DG)(DA)(DT)(DG)(DA)(DG)(DC)(DG)(DG)(DT)(DT)(DT)(DT)

TTTTTTTCATCGATGAGCACTGCTATTCCCTAGCAGTGCTCATCGATGATTTTCATCGATGAGCGGTTTT
Non polymer #3 ADP

InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
Non polymer #4 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #5 ZN

InChI=1S/Zn/q+2

[Zn+2]
Download coordinates
Reference