2026-08-22_00000426|hard|9WAE

Cryo-EM structure of helicase DruE in the Druantia anti-phage system elucidates its anti-phage mechanism; Electron microscopy 3.49Å
Protein #1 1970 residues (98% resolved)

MGSSHHHHHHSQDPMVLDPIGGFHRIQDFFISYVETSFRISNPTAAEARRALLKTCGILATEPFIEPVLRYESSDKNLEDLIEEEDGTLQPLSLEGRKAFVELALSGLFDGEPSKGLLRRKSAYAPYRHQISMLERGVRAGCPGIVTSGTGSGKTESFMLPVLAALANEAVDWPKPGVNYLQEHWWQTPKSRWSPRRAGEKRPAAVRALVLYPMNALVEDQMVRLRKTLDAEEAHAVMDERFTGNRLFFGQYTSATPVTGYEQHPRLAGDKQEVKRRARRIARLRKAMQNFQRDQDAARRFDADVQSDGKASVEKTRYIFPSVDGGEMVSRWDMHAAPPDILVTNASMLGAMLSREIEDAIFEKTREWLMSDEDAYFYLIFDELHLIRGSAGTEIALLIKSLIQRLGLDQPEHCYKLRLLASSASLPMEGVEGVQSRTYLRDLFAPFGTSSRPNDLGSIDPSFWSKCIIQGVVHIPPVQQCGIPAEPFVQLMKAALEGKDNFVGQLDRTPALDAAIVQAAKVLGITETEQTTLVKQLAETAASLLTHACKNDGTIRATTPRSIAARIFAPATGDTELALRGLLLARSLPESNQSAVKVAVATPAFRVHTFIRNIEGLFASVAPGEPDVAFDNFSVERGTSHSAPVEGQRRGHRLFELLYCEACGDLFVGGQRGQSSGSMNATELLPSAANLEHLPERPGAEYYDDMTLDEFAVFWPRRGDWIGSDKGYDQWEPAHLNPDTGIVEIGEIAKEGNIAGYLYYQTKAAVSKDKERSTQQPSAQPFCCPKCGTDYSNRPDTNRSRSPIRAFRTGVTKSSQLVATELFELLHAIGAEPKGIVFSDSRQDAAAQAMEIERLHLRDLRREVLVTAARSYVKDASIEVLTSKEIIERLIKAETAGDKDEVIRLSELLKKQTVACGPKTRKVKLDKLLEFGNDGSIGRITAELVRLGISPYKHSSSNDAKELPWYREFEKNGDLIAYDHTLSYTQTVGLNKDIVEGQYELIDDVIFANTFFALEETGLAYPCLPMDEDDQALDAWLRVFASAYRVKDNRYFDKNKVKLWQKGPDVTNGRIKKVARALYGETRYGDELTRVLGEFERLGHRGGLFNIGKLALKVTEPGDDFWRCSNCERVHLHRGLGVCTRCVAPLHEPSGKVEALWETNFLGRRIVRGERDGVGRFRLRVEELTGQTDDFSDRLRKFKGIFVDDVSELEKLASEIDMLSVTTTMEVGIDIGALQTVYQANMPPQRFNYQQRVGRAGRRGQAFSFVVTFCRGRSHDAYYFAHPQAITGDPPPPPFLATGHDAIPMRLLRKTWLRAAFKQLREQCAKLGESFPGDLLIPPDVHGEYVTTKDYYHSQEIDWPIRLSEALKQTQSVRDRFIETATFDQEQRQRLYAKSSIDLLLKEINDQRPHAPDDEVGLARFLAERGLLPMYGMPTRVRNLYVGLRESKTQSDHSEYEWSMMDRDLDLAVFEYAPGAVLVKDKKKHRVIGFTGNLTDPQAQGRSIEGIRSVTDWSESQTYVAICPACGSASQSKQAPEGPLACNDCQAPIPKESFLHYVTPAAFRTDFLPKDELDEFERMSLRTVATVLREGDCFNYRALTVRSGAGVTILQLNDGPTDGKNDGQRFTVDLVQDQRVPVPFSTQRPAIDGIQAIESSWRRSHISPRWSQPLSEQRFGLISQKETDSIHLELTRFDKRLTLDMVSRKGDFMHLPTRAAAISATQILVNKAALALDVSPDEFEALEPRLRSGHPMLQIADALINGSGLSRRLGEPASDGPTPLLVDLLHEILEKPNVWPLQDFLRTGAEGPHAAQCQTSCYRCIQRYGNRRYHGLLDWRLGLAYLRTLVTPAYACGLTPGDDKYPEIQGWRERASQLADDVEAMRKGTIRTERLPHSDLPCLIEQKDGVELWRAVVIHPLWRHSEPGVMRDLLGADWSPSLRYLDTFELERRPLRRLAALKQEGSWSHPQFEK

MGSSHHHHHHSQDPMVLDPIGGFHRIQDFFISYVETSFRISNPTAAEARRALLKTCGILATEPFIEPVLRYESSDKNLEDLIEEEDGTLQPLSLEGRKAFVELALSGLFDGEPSKGLLRRKSAYAPYRHQISMLERGVRAGCPGIVTSGTGSGKTESFMLPVLAALANEAVDWPKPGVNYLQEHWWQTPKSRWSPRRAGEKRPAAVRALVLYPMNALVEDQMVRLRKTLDAEEAHAVMDERFTGNRLFFGQYTSATPVTGYEQHPRLAGDKQEVKRRARRIARLRKAMQNFQRDQDAARRFDADVQSDGKASVEKTRYIFPSVDGGEMVSRWDMHAAPPDILVTNASMLGAMLSREIEDAIFEKTREWLMSDEDAYFYLIFDELHLIRGSAGTEIALLIKSLIQRLGLDQPEHCYKLRLLASSASLPMEGVEGVQSRTYLRDLFAPFGTSSRPNDLGSIDPSFWSKCIIQGVVHIPPVQQCGIPAEPFVQLMKAALEGKDNFVGQLDRTPALDAAIVQAAKVLGITETEQTTLVKQLAETAASLLTHACKNDGTIRATTPRSIAARIFAPATGDTELALRGLLLARSLPESNQSAVKVAVATPAFRVHTFIRNIEGLFASVAPGEPDVAFDNFSVERGTSHSAPVEGQRRGHRLFELLYCEACGDLFVGGQRGQSSGSMNATELLPSAANLEHLPERPGAEYYDDMTLDEFAVFWPRRGDWIGSDKGYDQWEPAHLNPDTGIVEIGEIAKEGNIAGYLYYQTKAAVSKDKERSTQQPSAQPFCCPKCGTDYSNRPDTNRSRSPIRAFRTGVTKSSQLVATELFELLHAIGAEPKGIVFSDSRQDAAAQAMEIERLHLRDLRREVLVTAARSYVKDASIEVLTSKEIIERLIKAETAGDKDEVIRLSELLKKQTVACGPKTRKVKLDKLLEFGNDGSIGRITAELVRLGISPYKHSSSNDAKELPWYREFEKNGDLIAYDHTLSYTQTVGLNKDIVEGQYELIDDVIFANTFFALEETGLAYPCLPMDEDDQALDAWLRVFASAYRVKDNRYFDKNKVKLWQKGPDVTNGRIKKVARALYGETRYGDELTRVLGEFERLGHRGGLFNIGKLALKVTEPGDDFWRCSNCERVHLHRGLGVCTRCVAPLHEPSGKVEALWETNFLGRRIVRGERDGVGRFRLRVEELTGQTDDFSDRLRKFKGIFVDDVSELEKLASEIDMLSVTTTMEVGIDIGALQTVYQANMPPQRFNYQQRVGRAGRRGQAFSFVVTFCRGRSHDAYYFAHPQAITGDPPPPPFLATGHDAIPMRLLRKTWLRAAFKQLREQCAKLGESFPGDLLIPPDVHGEYVTTKDYYHSQEIDWPIRLSEALKQTQSVRDRFIETATFDQEQRQRLYAKSSIDLLLKEINDQRPHAPDDEVGLARFLAERGLLPMYGMPTRVRNLYVGLRESKTQSDHSEYEWSMMDRDLDLAVFEYAPGAVLVKDKKKHRVIGFTGNLTDPQAQGRSIEGIRSVTDWSESQTYVAICPACGSASQSKQAPEGPLACNDCQAPIPKESFLHYVTPAAFRTDFLPKDELDEFERMSLRTVATVLREGDCFNYRALTVRSGAGVTILQLNDGPTDGKNDGQRFTVDLVQDQRVPVPFSTQRPAIDGIQAIESSWRRSHISPRWSQPLSEQRFGLISQKETDSIHLELTRFDKRLTLDMVSRKGDFMHLPTRAAAISATQILVNKAALALDVSPDEFEALEPRLRSGHPMLQIADALINGSGLSRRLGEPASDGPTPLLVDLLHEILEKPNVWPLQDFLRTGAEGPHAAQCQTSCYRCIQRYGNRRYHGLLDWRLGLAYLRTLVTPAYACGLTPGDDKYPEIQGWRERASQLADDVEAMRKGTIRTERLPHSDLPCLIEQKDGVELWRAVVIHPLWRHSEPGVMRDLLGADWSPSLRYLDTFELERRPLRRLAALKQEGSWSHPQFEK
Non polymer #2 ZN

InChI=1S/Zn/q+2

[Zn+2]
Download coordinates
Reference