2026-08-22_00000311|ligand|9NQL

Cryo electron microscopic analysis of the adduct of syringolin analog with the Mtb 20S proteasome; Electron microscopy 2.16Å
Protein #1 240 residues (93% resolved)

TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSGADTFGSDGGEKHHHHHH

TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSGADTFGSDGGEKHHHHHH
Protein #2 240 residues (89% resolved)

MEQAMRERSELARKGIARAKSVVALAYAGGVLFVAENPSRSLQKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLANVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKRPELYRITYDGSIADEPHFVVMGGTTEPIANALKESYAENASLTDALRIAVAALRAGSADTSGGDQPTLGVASLEVAVLDANRPRRAFRRITGSALQALLVDQESPQSDGESSG

MEQAMRERSELARKGIARAKSVVALAYAGGVLFVAENPSRSLQKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLANVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKRPELYRITYDGSIADEPHFVVMGGTTEPIANALKESYAENASLTDALRIAVAALRAGSADTSGGDQPTLGVASLEVAVLDANRPRRAFRRITGSALQALLVDQESPQSDGESSG
Non polymer #3 A1B0M

InChI=1S/C28H38N6O6/c1-17(2)25(27(38)40-3)34-28(39)31-16-24(36)33-22-10-6-7-13-29-23(35)12-11-19(32-26(22)37)14-18-15-30-21-9-5-4-8-20(18)21/h4-5,8-9,11-12,15,17,19,22,25,30H,6-7,10,13-14,16H2,1-3H3,(H,29,35)(H,32,37)(H,33,36)(H2,31,34,39)/t19-,22+,25-/m0/s1

CC(C)[C@@H](C(=O)OC)NC(=O)NCC(=O)N[C@@H]1CCCCNC(=O)C=C[C@H](NC1=O)Cc2c[nH]c3c2cccc3
Download coordinates
Reference