2026-08-22_00000294|hard|9IBC

Kinetoplastid ATP-dependent RNA helicase PRP22/DHX8 in closed conformation bound to pre-mRNA; Electron microscopy 3.51Å
Protein #1 706 residues (40% resolved)

MDWDRPSGKRRRTDEDEACEALGGLLRQTASRAMERVRLQRQQRGWESQLTILSSSAAAAVVRSVKPMDVLVIRFCLYYLDCSTVAAANHFVRLAQEVVTSSIERVLVPQLFSRDGSSLPALCEGLVTEHTAEEIQVTVKEVSEFVEARGALGAWIADATATRGDRDDDDYDDYDDADNYGGGYDDYSRSRDRDDGYSRLTNEEGEGDGEGDHGSPASPHKDTNDFALAITLYQACEFWARVQAFLNSLSLHSAHLHVFAMPPRYERELLLLLYTVTRGGGDHDEASVEAVALAGGSASRVGKGNNAGITPAEGASVSLSANAVAAKVKKKEAIKQESMWDSDDEVAAPVAGENCTDVEGAENTDVVEGPRQPQQLYRASALLADVLALSRCPDVPTASSSPPAGTTSEVALISSPLSAAAPRISAEATQRLQGLSPKFYKMVYARLGVMVARDRLHRFDRVSAITPPEFTVQQRNLQEQLLQQEQQQQYKADLMSAALGIPGQPEAGLPAAYVPDDTYYEKLLHQQHDTIDEDEEVYKGEVMDYYLSHPNRPGAATESSSSYSRARSHHRGSSARNGEAEPLMKPHRFCKVKMGFTWTQYNRTHYDSRTNPPPRTEMWYEFTLFYPALAHTKRDMRHIFRIEDTPEGPNDQYCLLVFSVGPPYADVAYRIRKKQWDTRRGGVRISFDQYGRYKLFFRFTNSNYRR

MDWDRPSGKRRRTDEDEACEALGGLLRQTASRAMERVRLQRQQRGWESQLTILSSSAAAAVVRSVKPMDVLVIRFCLYYLDCSTVAAANHFVRLAQEVVTSSIERVLVPQLFSRDGSSLPALCEGLVTEHTAEEIQVTVKEVSEFVEARGALGAWIADATATRGDRDDDDYDDYDDADNYGGGYDDYSRSRDRDDGYSRLTNEEGEGDGEGDHGSPASPHKDTNDFALAITLYQACEFWARVQAFLNSLSLHSAHLHVFAMPPRYERELLLLLYTVTRGGGDHDEASVEAVALAGGSASRVGKGNNAGITPAEGASVSLSANAVAAKVKKKEAIKQESMWDSDDEVAAPVAGENCTDVEGAENTDVVEGPRQPQQLYRASALLADVLALSRCPDVPTASSSPPAGTTSEVALISSPLSAAAPRISAEATQRLQGLSPKFYKMVYARLGVMVARDRLHRFDRVSAITPPEFTVQQRNLQEQLLQQEQQQQYKADLMSAALGIPGQPEAGLPAAYVPDDTYYEKLLHQQHDTIDEDEEVYKGEVMDYYLSHPNRPGAATESSSSYSRARSHHRGSSARNGEAEPLMKPHRFCKVKMGFTWTQYNRTHYDSRTNPPPRTEMWYEFTLFYPALAHTKRDMRHIFRIEDTPEGPNDQYCLLVFSVGPPYADVAYRIRKKQWDTRRGGVRISFDQYGRYKLFFRFTNSNYRR
Protein #2 1087 residues (74% resolved)

MNAVGSTVGLVDSDDDAIAEQQNMSFLMKLQELYCKTVLYDQLEQMMGHPATQEESDGYLDDVEGLVKLYYSEMEAAKKMVPKGEEPSTAAQREVTEQHILHSLSVAINGGAEADEEPDVPISSIQKLYHVLHGCLTTDTVETGLAVGSLLLADDAKRSAEEAARLAYQQQQRHMHGGVDTASMNTSTVERKNAMKVSPEEMFRLAQHVRSGLADEAELLKLRSEDNEENGDGAQDVELNDEEPRFLRNMGFSSMLHRRINYRAPLPSQQLRDARTPQHRQAILDRLAQRQQGDTSKLNSMEAVAQMQEKINMDRRVIARKAQRAQQQSREYDFGAAISGREGKLVLDEGRYGRRGEALESEEYSVQPTLLHSELNALPEEGGFRPQDLPTKLAPWMKHSFGNKPRFGLPETMQTIQEQRVSLPIYAKKEALLNFVDAHRVTVLVGETGSGKTTQIPQYLAEHGYADRGMIACTQPRRVAAETLAMRVAEEYGCRLGEEVGYTVRFRDVTSSLTKIKYMTDGMLLREALLDDSFQRYSVIILDEAHERSISTDLLFAIVRQALRKNEVLKVMVTSATLETEKFCAYFGASEPFRIEGRTFPVETYYLTDPTTDYVRTALQTVMMIHLQEPPGDVLVFFTGQEEIELGGEQLFRWMEMLRRQVSTPLPDLMVLPLTATMPQEVQSKVFEPTPPGCRKVVLATNVAETSITITNLYYVVDSGFCKQNIFDAKHGIDQLKVMPVSQAQAKQRSGRAGRIGPGKCYRMYTEKQFTTDMVPETVPDIMRTSLFHVTLQLKAMGLDLLSLELMDCPPKGAIVSALEKLRYLEALDDDGLLTPLGSRMAQLSIDPSQSKTLLTAVDLGCSEPVLTIVSMLAVQKRGVFYRPRDQQDASDAARRQFMQPEGDQLTLMAVYDAWVENGMSEDWCKHNFLKHRMLVEARDTRDQLKEMLARRNQHISHENDTNLDEVRKSITAGYFFNAARRVDSHTRSYVTLSDRREVYVHPSSVLIDDPPKYVLYDDLRMTKREYMTELLAIEPKWLVELAPAFYAKPKEGRLTKEQAAERFTPILKSWETGSSWRISRLKKQRR

MNAVGSTVGLVDSDDDAIAEQQNMSFLMKLQELYCKTVLYDQLEQMMGHPATQEESDGYLDDVEGLVKLYYSEMEAAKKMVPKGEEPSTAAQREVTEQHILHSLSVAINGGAEADEEPDVPISSIQKLYHVLHGCLTTDTVETGLAVGSLLLADDAKRSAEEAARLAYQQQQRHMHGGVDTASMNTSTVERKNAMKVSPEEMFRLAQHVRSGLADEAELLKLRSEDNEENGDGAQDVELNDEEPRFLRNMGFSSMLHRRINYRAPLPSQQLRDARTPQHRQAILDRLAQRQQGDTSKLNSMEAVAQMQEKINMDRRVIARKAQRAQQQSREYDFGAAISGREGKLVLDEGRYGRRGEALESEEYSVQPTLLHSELNALPEEGGFRPQDLPTKLAPWMKHSFGNKPRFGLPETMQTIQEQRVSLPIYAKKEALLNFVDAHRVTVLVGETGSGKTTQIPQYLAEHGYADRGMIACTQPRRVAAETLAMRVAEEYGCRLGEEVGYTVRFRDVTSSLTKIKYMTDGMLLREALLDDSFQRYSVIILDEAHERSISTDLLFAIVRQALRKNEVLKVMVTSATLETEKFCAYFGASEPFRIEGRTFPVETYYLTDPTTDYVRTALQTVMMIHLQEPPGDVLVFFTGQEEIELGGEQLFRWMEMLRRQVSTPLPDLMVLPLTATMPQEVQSKVFEPTPPGCRKVVLATNVAETSITITNLYYVVDSGFCKQNIFDAKHGIDQLKVMPVSQAQAKQRSGRAGRIGPGKCYRMYTEKQFTTDMVPETVPDIMRTSLFHVTLQLKAMGLDLLSLELMDCPPKGAIVSALEKLRYLEALDDDGLLTPLGSRMAQLSIDPSQSKTLLTAVDLGCSEPVLTIVSMLAVQKRGVFYRPRDQQDASDAARRQFMQPEGDQLTLMAVYDAWVENGMSEDWCKHNFLKHRMLVEARDTRDQLKEMLARRNQHISHENDTNLDEVRKSITAGYFFNAARRVDSHTRSYVTLSDRREVYVHPSSVLIDDPPKYVLYDDLRMTKREYMTELLAIEPKWLVELAPAFYAKPKEGRLTKEQAAERFTPILKSWETGSSWRISRLKKQRR
Protein #3 403 residues (10% resolved)

MSNSVWALAVSTTSPSDLPAGDEVEQIVCRSLEENAYSVQGFWLWQSNFIQSRRRREQRRRRQRNDVASPTKEGSGESAPTRSEAEEASLQRADEIRGYVSAVLHATGYPYPFASTADDAREGADDPAPSTVTDAETAVTSDGLTPASLCSTITDSAAVSGEPPLKVNRGEGTGATARIPARPASALAKFVAKARAQHCDLVEHAPVVVATVPARWAELDEPGTQPGMGRKRIQFSDEPPLVKTPQLSSRGHIRRDNGDNDDDDSFTVQLPAHMGLQSSSNKDKSDGHSMDAGAGGAGGAEAVAAKHPSQMTRAEFLSQFKRAPRRGEVGQTAEEIAAAEKLGYVMSGSRSVASRMYVDRIQRQLHEHEAAKLQQQFRKVEDERMDDQLVLGLAQFINSKAKS

MSNSVWALAVSTTSPSDLPAGDEVEQIVCRSLEENAYSVQGFWLWQSNFIQSRRRREQRRRRQRNDVASPTKEGSGESAPTRSEAEEASLQRADEIRGYVSAVLHATGYPYPFASTADDAREGADDPAPSTVTDAETAVTSDGLTPASLCSTITDSAAVSGEPPLKVNRGEGTGATARIPARPASALAKFVAKARAQHCDLVEHAPVVVATVPARWAELDEPGTQPGMGRKRIQFSDEPPLVKTPQLSSRGHIRRDNGDNDDDDSFTVQLPAHMGLQSSSNKDKSDGHSMDAGAGGAGGAEAVAAKHPSQMTRAEFLSQFKRAPRRGEVGQTAEEIAAAEKLGYVMSGSRSVASRMYVDRIQRQLHEHEAAKLQQQFRKVEDERMDDQLVLGLAQFINSKAKS
Protein #4 1181 residues (4% resolved)

MDFSFPHFTRASTDMVYTQPPLKSLLELVIEAKGRLGLVPQRDVVRHHPSSSPFSHFSDSDEEGEGADRNANKAEVRQDAVLTTRTSWVPPSYLLDYFFSGEFLSVFLTLHGISASRPVSMLVPPLFTVRDAQLHPLVEAGLCSVLQDALHSSSRQHRSGGGGGWREGVRGGRGGGGDGGGEGSYMESNAAGTSGGGPFMPYWKGPRQHHLQGGVLGAGEGNDNEAAEQSASGAAHPRCVYAQHRVDDPAFILPPQRFLFRGLQQVALPALLLGDHVLMGGPRGIGKRTAALLSVGANVLAFTSNVDSGTAEETDAPPALVEGEGGAAADGASAAVTGPVPISPADAEALQQEAVEDTRDAATSRPEPVSPPAPRALIVLSSYPEVLSAAHWLRSVFGAEAFTPYTFEKEGTALRPLFEVDTAEQQPAALDGGSKAASSSDAFGHVGAMNTFPETTGTRRFIGPPVSLPFITDTIGAARAPELLLVDPTQTDSAPLHSETTAPALAELAALVMNVPLPAQAADTAQATAGERASGGDSKLKRRRHREDEVDSDVEADEEHVETRSSRTHRRHHRHRSERDEVESEDDEIRRGRHREKRSPHSRSRHRHHSRHGDRRDRREEEGSRGERNASGHRSHRRHHRRSYESDDSDSDRDKGKWPIEDEDTHSPRHSRHQRGCRDHRHHSSGGSVSRRHRSRSDERRSRHGSSRHRHHRSRHHRDHHDEDQRSVSSSSTATSSPSSPGFQLARPPSLMPTNVEAELPMMPGNHVAPPAADELRALALDSIVPPAVANETSAPSEKPQEAAEEDRRAELSDVLHQRIPLLITTYHALGMALGMVQGEASALPPLEHVRVALLANLERVLMPPLKMSFAHSWWLSLVNALDVECQFVVTADRMGNEVRGFLDSTIIPDAGERFVHFDQRDASIWAMMNVQVCAVPVDVPVSAAPPNGGSEGRPRISGSDIDAAKVAHVFSTIAEHMLRTGGHATHGKDDVAFQADCGGRGACVAVVCSTRREQSLVVTQLQRLFQDQANDTQAAKGVRVTEKVELFRAAEAEVLVLTDAQLADPRVLRDLHQCTEVDLILHFSLSRTVMAQLKKEEIIDLLAQRGRAILGGSKQFCARRWWRGTAMTSAAGGGAAFGVPSNAVDFEPVKVECQLLLTEHNVHGRVGSCVMEALREVSDS

MDFSFPHFTRASTDMVYTQPPLKSLLELVIEAKGRLGLVPQRDVVRHHPSSSPFSHFSDSDEEGEGADRNANKAEVRQDAVLTTRTSWVPPSYLLDYFFSGEFLSVFLTLHGISASRPVSMLVPPLFTVRDAQLHPLVEAGLCSVLQDALHSSSRQHRSGGGGGWREGVRGGRGGGGDGGGEGSYMESNAAGTSGGGPFMPYWKGPRQHHLQGGVLGAGEGNDNEAAEQSASGAAHPRCVYAQHRVDDPAFILPPQRFLFRGLQQVALPALLLGDHVLMGGPRGIGKRTAALLSVGANVLAFTSNVDSGTAEETDAPPALVEGEGGAAADGASAAVTGPVPISPADAEALQQEAVEDTRDAATSRPEPVSPPAPRALIVLSSYPEVLSAAHWLRSVFGAEAFTPYTFEKEGTALRPLFEVDTAEQQPAALDGGSKAASSSDAFGHVGAMNTFPETTGTRRFIGPPVSLPFITDTIGAARAPELLLVDPTQTDSAPLHSETTAPALAELAALVMNVPLPAQAADTAQATAGERASGGDSKLKRRRHREDEVDSDVEADEEHVETRSSRTHRRHHRHRSERDEVESEDDEIRRGRHREKRSPHSRSRHRHHSRHGDRRDRREEEGSRGERNASGHRSHRRHHRRSYESDDSDSDRDKGKWPIEDEDTHSPRHSRHQRGCRDHRHHSSGGSVSRRHRSRSDERRSRHGSSRHRHHRSRHHRDHHDEDQRSVSSSSTATSSPSSPGFQLARPPSLMPTNVEAELPMMPGNHVAPPAADELRALALDSIVPPAVANETSAPSEKPQEAAEEDRRAELSDVLHQRIPLLITTYHALGMALGMVQGEASALPPLEHVRVALLANLERVLMPPLKMSFAHSWWLSLVNALDVECQFVVTADRMGNEVRGFLDSTIIPDAGERFVHFDQRDASIWAMMNVQVCAVPVDVPVSAAPPNGGSEGRPRISGSDIDAAKVAHVFSTIAEHMLRTGGHATHGKDDVAFQADCGGRGACVAVVCSTRREQSLVVTQLQRLFQDQANDTQAAKGVRVTEKVELFRAAEAEVLVLTDAQLADPRVLRDLHQCTEVDLILHFSLSRTVMAQLKKEEIIDLLAQRGRAILGGSKQFCARRWWRGTAMTSAAGGGAAFGVPSNAVDFEPVKVECQLLLTEHNVHGRVGSCVMEALREVSDS
RNA #5 7 bases

UUUUUUU

UUUUUUU
Download coordinates
Reference