2026-08-22_00000103|medium|21NY

Cryo-EM structure of the rat IgE-Fc in complex with FcgammaRIIB; Electron microscopy 3.39Å
Protein #1 255 residues (67% resolved)

MDSNRTVVHVLSRTLYHMLLWTAVLNLVAESHAGLPKAVVKLEPPWIQVLKEDTVTLMCEGTHNTKNCSTQWFHNGSSIWHQAQANYTFKATVNDSGEYRCRMEETGISEPIHLGVISDWLLLQTSQLVFEEGETITLRCHSWKNKQLTKVLLFQNGKPVRYYHQSSNFSIPKANHSHSGNYYCKAYLGRTMHVSKPVTITVQEPKSSSSLPGGSHHHHHHHHGSSAWSHPQFEKGGGSGGGSGGSAWSHPQFEK

MDSNRTVVHVLSRTLYHMLLWTAVLNLVAESHAGLPKAVVKLEPPWIQVLKEDTVTLMCEGTHNTKNCSTQWFHNGSSIWHQAQANYTFKATVNDSGEYRCRMEETGISEPIHLGVISDWLLLQTSQLVFEEGETITLRCHSWKNKQLTKVLLFQNGKPVRYYHQSSNFSIPKANHSHSGNYYCKAYLGRTMHVSKPVTITVQEPKSSSSLPGGSHHHHHHHHGSSAWSHPQFEKGGGSGGGSGGSAWSHPQFEK
Protein #2 363 residues (87% resolved)

MSVPTQVLGLLLLWLTDARCDIARPVNITKPTVDLLHSSCDPNAFHSTIQLYCFVYGHIQNDVSIHWLMDDRKIYETHAQNVLIKEEGKLASTYSRLNITQQQWMSESTFTCKVTSQGENYWAHTRRCSDDEPRGVITYLIPPSPLDLYENGTPKLTCLVLDLESEENITVTWVRERKKSIGSASQRSTKHHNATTSITSILPVDAKDWIEGEGYQCRVDHPHFPKPIVRSITKAPGKRSAPEVYVFLPPEEEEKDKRTLTCLIQNFFPEDISVQWLQDSKLIPKSQHSTTTPLKYNGSNQRFFIFSRLEVTKALWTQTKQFTCRVIHEALREPRKLERTISKSLGNTSLRPSQASMHHHHHH

MSVPTQVLGLLLLWLTDARCDIARPVNITKPTVDLLHSSCDPNAFHSTIQLYCFVYGHIQNDVSIHWLMDDRKIYETHAQNVLIKEEGKLASTYSRLNITQQQWMSESTFTCKVTSQGENYWAHTRRCSDDEPRGVITYLIPPSPLDLYENGTPKLTCLVLDLESEENITVTWVRERKKSIGSASQRSTKHHNATTSITSILPVDAKDWIEGEGYQCRVDHPHFPKPIVRSITKAPGKRSAPEVYVFLPPEEEEKDKRTLTCLIQNFFPEDISVQWLQDSKLIPKSQHSTTTPLKYNGSNQRFFIFSRLEVTKALWTQTKQFTCRVIHEALREPRKLERTISKSLGNTSLRPSQASMHHHHHH
Non polymer #3 BMA

InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1

C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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Reference