2026-08-15_00000175|hard|9TQ4

Asp2Cas12l-sgRNA bound to target DNA; Electron microscopy 2.51Å
Protein #1 867 residues (95% resolved)

MGKNRSSSSDLSPLERSLRKVGENRLERLRVREEKIRKHIEQHPRGKNDHQALHFLLHQIEVERNDLYRNLKDPEYVPKPAKQRRERRQINVAKPPTRPKKEKGPQPESTKYVIRPPVPGKNLPAFASKYEARDTRDDSYQDGRSWTSAPYVEVELPILGADKVIQKLMKFVQKDERSIVRDWATKTYSSIEAAREALLVGAQVSEDVSVWRGLLAETKNAQNFAALSDDQIEAAMSKEAKGADLRPRRAALLVAQRHWVDQTVKAIKESAPSGVDKDTLDRRLRAGLRGFHTAANSGKHTNPQFPYLTAEKPVVPMESVVQSVLAFLDDPDDQRYTKDKEDDKKRHRVTVLQKELGKARPRKRLELQTPKWAGRPTVKGTISKRRDAALVWDTSKEANGLCLALPIGGMPKIDVEQFIYQDGTSLLSDCQIASKTTKKGAACAVLPLKPKHDFLRWFTKHVENHNPDAPLERRCLHNTTQFVIVDPEGPRPRLFVRPVFKFYDPGKTVPNTHETWKKPDCRYLVGIDRGINYVLRAVVVDTEEKKVIADIGLPGRKHEWRMIRDEIAYHQQMRDLARNTGKHASVVAKHVRALALARKKDRALGKFATVEAVAELVKKCEQDYGSGNYCFVLEDLDMGAMNLKRNNRVKHMAVMEEALVNQMRKQGYAYDGRRGRVDGVRHEGAWYTSQVSPFGWWAKRDEVEEAWKRDKTRPIGRKVGNWYEMPEPGQDGDRPDTYRKGYWSKPKNAEGKPYGRNRFSVEPGDEKPDAERRFCWGSELFWDPNVKSFKGKEFPEGVVLDADFVGALNIALRPLVNDGQGKGFKAEDMAREHTILNPQFKIACQIPVYEFVEEDGDKWAALRRIML

MGKNRSSSSDLSPLERSLRKVGENRLERLRVREEKIRKHIEQHPRGKNDHQALHFLLHQIEVERNDLYRNLKDPEYVPKPAKQRRERRQINVAKPPTRPKKEKGPQPESTKYVIRPPVPGKNLPAFASKYEARDTRDDSYQDGRSWTSAPYVEVELPILGADKVIQKLMKFVQKDERSIVRDWATKTYSSIEAAREALLVGAQVSEDVSVWRGLLAETKNAQNFAALSDDQIEAAMSKEAKGADLRPRRAALLVAQRHWVDQTVKAIKESAPSGVDKDTLDRRLRAGLRGFHTAANSGKHTNPQFPYLTAEKPVVPMESVVQSVLAFLDDPDDQRYTKDKEDDKKRHRVTVLQKELGKARPRKRLELQTPKWAGRPTVKGTISKRRDAALVWDTSKEANGLCLALPIGGMPKIDVEQFIYQDGTSLLSDCQIASKTTKKGAACAVLPLKPKHDFLRWFTKHVENHNPDAPLERRCLHNTTQFVIVDPEGPRPRLFVRPVFKFYDPGKTVPNTHETWKKPDCRYLVGIDRGINYVLRAVVVDTEEKKVIADIGLPGRKHEWRMIRDEIAYHQQMRDLARNTGKHASVVAKHVRALALARKKDRALGKFATVEAVAELVKKCEQDYGSGNYCFVLEDLDMGAMNLKRNNRVKHMAVMEEALVNQMRKQGYAYDGRRGRVDGVRHEGAWYTSQVSPFGWWAKRDEVEEAWKRDKTRPIGRKVGNWYEMPEPGQDGDRPDTYRKGYWSKPKNAEGKPYGRNRFSVEPGDEKPDAERRFCWGSELFWDPNVKSFKGKEFPEGVVLDADFVGALNIALRPLVNDGQGKGFKAEDMAREHTILNPQFKIACQIPVYEFVEEDGDKWAALRRIML
RNA #2 164 bases

UUAGGCGUUCCGUCUCGACUAUGCCGUACCACUAGACCGAGCCUACACGGCACGCGGUCAUAGCGUUAACCAAGGCGUGGUGACAAGCCUCUUUCAGGCGUCGGACACUUAAGAGCGUUGAAAAACGCUCUUAGGGAAUGAAAGGCCUUCAGAAGAGGGUGCAU

UUAGGCGUUCCGUCUCGACUAUGCCGUACCACUAGACCGAGCCUACACGGCACGCGGUCAUAGCGUUAACCAAGGCGUGGUGACAAGCCUCUUUCAGGCGUCGGACACUUAAGAGCGUUGAAAAACGCUCUUAGGGAAUGAAAGGCCUUCAGAAGAGGGUGCAU
DNA #3 47 bases

(DT)(DA)(DC)(DG)(DA)(DG)(DC)(DC)(DA)(DC)(DC)(DC)(DC)(DG)(DG)(DA)(DA)(DG)(DT)(DC)(DT)(DT)(DC)(DT)(DC)(DC)(DC)(DA)(DC)(DG)(DT)(DA)(DA)(DA)(DG)(DC)(DG)(DT)(DA)(DT)(DA)(DG)(DT)(DG)(DT)(DG)(DC)

TACGAGCCACCCCGGAAGTCTTCTCCCACGTAAAGCGTATAGTGTGC
DNA #4 47 bases

(DG)(DC)(DA)(DC)(DA)(DC)(DT)(DA)(DT)(DA)(DC)(DG)(DG)(DA)(DA)(DA)(DT)(DG)(DC)(DA)(DC)(DC)(DC)(DT)(DC)(DT)(DT)(DC)(DT)(DG)(DA)(DA)(DG)(DG)(DC)(DG)(DG)(DG)(DT)(DG)(DG)(DC)(DT)(DC)(DG)(DT)(DA)

GCACACTATACGGAAATGCACCCTCTTCTGAAGGCGGGTGGCTCGTA
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Reference