2026-08-08_00000276|hard|9WHX

Cryo-EM structure of the IS621 recombinase in complex with bridge RNA, left-half DNA, and right-half DNA in the pre-strand exchange state; Electron microscopy 2.50Å
Protein #1 328 residues (97% resolved)

GPMEHELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRHNPVAA

GPMEHELHYIGIDTAKEKLDVDVLRPDGRHRTKKFANTTKGHDELVSWLKGHKIDHAHICIEATGTYMEPVAECLYDAGYIVSVINPALGKAFAQSEGLRNKTDTVDARMLAEFCRQKRPAAWEAPHPLERALRALVVRHQALTDMHTQELNRTETAREVQRPSIDAHLLWLEAELKRLEKQIKDLTDDDPDMKHRRKLLESIPGIGEKTSAVLLAYIGLKDRFAHARQFAAFAGLTPRRYESGSSVRGASRMSKAGHVSLRRALYMPAMVATSKTEWGRAFRDRLAANGKKGKVILGAMMRKLAQVAYGVLKSGVPFDASRHNPVAA
RNA #2 180 bases

GGGAGUGCAGAGAAAAUCGGCCAGUUUUCUCUGCCUGCAGUCCGCAUGCCGUAUCGGGCCUUGGGUUCUAACCUGUUCUGUAGAUUUAUGCAGCGGACUGCCUUUCUCCCAAAGUGAUAAACCGGACAGUAUCAUGGACCGGUUUUCCCGGUAAUCCGUAUUUACAAGGCUGGUUUCACU

GGGAGUGCAGAGAAAAUCGGCCAGUUUUCUCUGCCUGCAGUCCGCAUGCCGUAUCGGGCCUUGGGUUCUAACCUGUUCUGUAGAUUUAUGCAGCGGACUGCCUUUCUCCCAAAGUGAUAAACCGGACAGUAUCAUGGACCGGUUUUCCCGGUAAUCCGUAUUUACAAGGCUGGUUUCACU
DNA #3 38 bases

(DG)(DC)(DC)(DG)(DG)(DG)(DT)(DA)(DA)(DT)(DA)(DC)(DC)(DA)(DC)(DC)(DA)(DA)(DG)(DC)(DC)(DG)(DC)(DC)(DT)(DT)(DG)(DT)(DA)(DT)(DT)(DA)(DT)(DC)(DC)(DC)(DT)(DC)

GCCGGGTAATACCACCAAGCCGCCTTGTATTATCCCTC
DNA #4 38 bases

(DG)(DA)(DG)(DG)(DG)(DA)(DT)(DA)(DA)(DT)(DA)(DC)(DA)(DA)(DG)(DG)(DC)(DC)(DC)(DG)(DA)(DT)(DG)(DG)(DT)(DG)(DG)(DT)(DA)(DT)(DT)(DA)(DC)(DC)(DC)(DG)(DG)(DC)

GAGGGATAATACAAGGCCCGATGGTGGTATTACCCGGC
DNA #5 44 bases

(DT)(DG)(DC)(DA)(DG)(DG)(DC)(DC)(DA)(DT)(DA)(DA)(DG)(DT)(DC)(DA)(DA)(DT)(DC)(DT)(DA)(DC)(DA)(DG)(DA)(DT)(DG)(DA)(DG)(DC)(DT)(DC)(DG)(DC)(DC)(DC)(DC)(DA)(DA)(DC)(DG)(DA)(DG)(DG)

TGCAGGCCATAAGTCAATCTACAGATGAGCTCGCCCCAACGAGG
DNA #6 44 bases

(DC)(DC)(DT)(DC)(DG)(DT)(DT)(DG)(DG)(DG)(DG)(DC)(DG)(DA)(DG)(DC)(DT)(DC)(DA)(DT)(DC)(DT)(DG)(DT)(DA)(DG)(DA)(DT)(DA)(DC)(DT)(DG)(DT)(DT)(DA)(DT)(DG)(DG)(DC)(DC)(DT)(DG)(DC)(DA)

CCTCGTTGGGGCGAGCTCATCTGTAGATACTGTTATGGCCTGCA
Non polymer #7 MG

InChI=1S/Mg/q+2

[Mg+2]
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Reference