2026-08-08_00000046|ligand|24UY

Crystal structure of FPP-methyltransferase PcFPPMT from Pseudomonas chlororaphis O6 in complex with SAH and GPP; X-ray diffraction 1.70Å
Protein #1 311 residues (96% resolved)

GAGAGAGAGAGALPYHVIRGAEVSGYEGKVVYTYQDDPEDWRKAIGDRLMFQFGVYDDPRSRPPISPDESGLRYFDRQMELAGYGRGDFGPVKRILDVGCGWGFGLKYLADRFPACPRLDGINISARQLEYCAKYHAEHRLSERINLYLCNAQDVDLLPHADEPYDLVTVRGVISHFPNDLYERSMAKLASRLRPGATVIISDNLYNLPLEQYRSDTADDVDRLACKHRKTPGYFRQVLEQCGLNVEDMRVLPENIDVARWFMDVKKNIETHFTPDTIPPPLEELRVMAVNVSVALIKDQFSTYSVIARHP

GAGAGAGAGAGALPYHVIRGAEVSGYEGKVVYTYQDDPEDWRKAIGDRLMFQFGVYDDPRSRPPISPDESGLRYFDRQMELAGYGRGDFGPVKRILDVGCGWGFGLKYLADRFPACPRLDGINISARQLEYCAKYHAEHRLSERINLYLCNAQDVDLLPHADEPYDLVTVRGVISHFPNDLYERSMAKLASRLRPGATVIISDNLYNLPLEQYRSDTADDVDRLACKHRKTPGYFRQVLEQCGLNVEDMRVLPENIDVARWFMDVKKNIETHFTPDTIPPPLEELRVMAVNVSVALIKDQFSTYSVIARHP
Non polymer #2 GPP

InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/b10-7+

CC(=CCC/C(=C/CO[P@@](=O)(O)OP(=O)(O)O)/C)C
Non polymer #3 IMD

InChI=1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)/p+1

c1c[nH+]c[nH]1
Non polymer #4 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #5 SAH

InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1

c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
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Reference