2026-08-08_00000025|hard|22QS

Cryo-EM structure of the Deg-3/Des-2 apo state; Electron microscopy 2.57Å
Protein #1 548 residues (72% resolved)

MLIIIQSLLLATTASLCIADTPVPTQIRLVHDLLDNYDKKAKPMWDNSKPINVSFSMDLYQILELNEPQQYILLNAWIIERWFDEFLYWNPDDYENITELRLPYDSIWLPDTTLYNSLVMKDDDTRRLLNSKLTTDTHRRAALIELLYPTIYKFSCLLDLRFFPFDVQVCTMTFSSWTYDQKGIDYFPYSDKIGTSNYLENEGWYILQTKIKRQEVKYACCPNNYTLLQLTLYLRRKPLFYLVNLIIPTSIITLIAIVGFFTTSSASGMREEKVSLGITTLLSMSILMLMVSDQMPTTSTFIPLIGWFILAMIIVISLGTVVSSVIIAIQKRGSLGERMSKRALKFAKVLAWFTCTSLPPHVEKEHMMEAFDAPTPLVEVRPLQLASVKESVRNKWVSGARRATQRGNSGLALISDKSTDPLIHLSPTAHQPDESISPSAPPVPSSSPLPPPLTPGPADDVVSVASELSSKFLTSRMRPKSQKDNTFAAMQSSIKANRQLAVAEFEWFATVVERTCFVIFVVAFLIITFGINFIGFIHWHQAGVEYGG

MLIIIQSLLLATTASLCIADTPVPTQIRLVHDLLDNYDKKAKPMWDNSKPINVSFSMDLYQILELNEPQQYILLNAWIIERWFDEFLYWNPDDYENITELRLPYDSIWLPDTTLYNSLVMKDDDTRRLLNSKLTTDTHRRAALIELLYPTIYKFSCLLDLRFFPFDVQVCTMTFSSWTYDQKGIDYFPYSDKIGTSNYLENEGWYILQTKIKRQEVKYACCPNNYTLLQLTLYLRRKPLFYLVNLIIPTSIITLIAIVGFFTTSSASGMREEKVSLGITTLLSMSILMLMVSDQMPTTSTFIPLIGWFILAMIIVISLGTVVSSVIIAIQKRGSLGERMSKRALKFAKVLAWFTCTSLPPHVEKEHMMEAFDAPTPLVEVRPLQLASVKESVRNKWVSGARRATQRGNSGLALISDKSTDPLIHLSPTAHQPDESISPSAPPVPSSSPLPPPLTPGPADDVVSVASELSSKFLTSRMRPKSQKDNTFAAMQSSIKANRQLAVAEFEWFATVVERTCFVIFVVAFLIITFGINFIGFIHWHQAGVEYGG
Protein #2 564 residues (66% resolved)

MTLKIRTIIILFCVISVTTTSQSLNATLKTFDPRLLNSTADRDIAMKNVPLVRLTRHLLSPERYDVRVRPILDHKKSLKVHISISLYQIIEVDEPSQNIKLNVWMIQKWRDEYLDWNPNEYGMINSTIIPFHHLWIPDTYLYNSVKMSRDETERYMNIQATSNYWKGEKGAELSFLYPAIYTITCRLNIRFFPYDRQNCTLTISSWTNSKSALDYYADTEVSMQSFIPNEEWQVKSFKIHRHEYKYACCAEPWVILQASLVIQRKPLYYLVNLIIPTSIITLVAITGFFTPASTDDDRTEKINLGITTLLAMSILMLMVSDQMPTTSEFVPLIAWFYLSIIIIISIGTFLTSVVLSVQGRRQYGRNPPQFIRYIFFVLLPQVLLLNVPPPLQTLWGELDDDPLNVRRRKKSHYLSRNVNNGSTKMASPMSTLRVPQSAGSVSEKRQSFQMIDVTSPNSPNTARSRAPSLAPSTAKATMWEGTMSALAGTNTQLRRTSNVFNKEVDEMRRKRQCSLEWEFLATVLDRFLLIVFVGAVVIVTAGLILVGRMAQYSYDHPDDRFFNV

MTLKIRTIIILFCVISVTTTSQSLNATLKTFDPRLLNSTADRDIAMKNVPLVRLTRHLLSPERYDVRVRPILDHKKSLKVHISISLYQIIEVDEPSQNIKLNVWMIQKWRDEYLDWNPNEYGMINSTIIPFHHLWIPDTYLYNSVKMSRDETERYMNIQATSNYWKGEKGAELSFLYPAIYTITCRLNIRFFPYDRQNCTLTISSWTNSKSALDYYADTEVSMQSFIPNEEWQVKSFKIHRHEYKYACCAEPWVILQASLVIQRKPLYYLVNLIIPTSIITLVAITGFFTPASTDDDRTEKINLGITTLLAMSILMLMVSDQMPTTSEFVPLIAWFYLSIIIIISIGTFLTSVVLSVQGRRQYGRNPPQFIRYIFFVLLPQVLLLNVPPPLQTLWGELDDDPLNVRRRKKSHYLSRNVNNGSTKMASPMSTLRVPQSAGSVSEKRQSFQMIDVTSPNSPNTARSRAPSLAPSTAKATMWEGTMSALAGTNTQLRRTSNVFNKEVDEMRRKRQCSLEWEFLATVLDRFLLIVFVGAVVIVTAGLILVGRMAQYSYDHPDDRFFNV
Non polymer #3 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
Download coordinates
Reference