2026-08-08_00000013|ligand|12LC

Crystal structure of human KRAS G12C covalently bound to AM-8719; X-ray diffraction 1.90Å
Protein #1 183 residues (92% resolved)

MKHHHHHHHDEVDGMTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEK

MKHHHHHHHDEVDGMTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEK
Non polymer #2 A1DI7

InChI=1S/C31H42F3N7O3/c1-5-26(42)40-14-12-38(13-15-40)23-17-41(21(23)3)25-16-24(36-29(37-25)31(32,33)34)39-10-7-22(8-11-39)27-20(2)6-9-35-28(27)30(43-4)18-44-19-30/h6,9,16,21-23H,5,7-8,10-15,17-19H2,1-4H3/t21-,23-/m1/s1

CCC(=O)N1CCN(CC1)[C@@H]2CN([C@@H]2C)c3cc(nc(n3)C(F)(F)F)N4CCC(CC4)c5c(ccnc5C6(COC6)OC)C
Non polymer #3 GDP

InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1

c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
Non polymer #4 MG

InChI=1S/Mg/q+2

[Mg+2]
Download coordinates
Reference